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N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

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N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:JK184
CAS:315703-52-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:JK-184
CAS:315703-52-7
Purity:98% Package:100mg Remarks:BOC Sciences also provides custom synthesis services for JK-184.
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:n-(4-ethoxyphenyl)-4-(2-methylimidazo(1,2-a)pyridin-3-yl)thiazol-2-amine
CAS:315703-52-7
Purity:0.99 Package:1kg
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: factory@coreychem.com
Products Intro: Product Name:N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
CAS:315703-52-7
Purity:97%-99.9% Package:1KG;1USD
Company Name: Zhejiang J&C Biological Technology Co.,Limited
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Email: sales@sarms4muscle.com
Products Intro: Product Name:JK184
CAS:315703-52-7
Purity:99% Package:5KG;1KG Remarks:JK184

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine manufacturers
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Basic information
Product Name:N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
Synonyms:N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine;Hh Signaling Antagonist VII, JK184;JK 184;N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine;2-ThiazolaMine, N-(4-ethoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyridin-3-yl)-;Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem;CS-2369;JK184 (JK-184
CAS:315703-52-7
MF:C19H18N4OS
MW:350.44
EINECS:
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Mol File:315703-52-7.mol
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Structure
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Chemical Properties
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility DMSO: ≥20mg/mL
form powder
color off-white to light brown
Safety Information
Hazard Codes Xn
Risk Statements 22-41
Safety Statements 26-36
WGK Germany 3
MSDS Information
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Usage And Synthesis
UsesJK 184 is a small molecule antagonist of the Hedgehog (Hh) signaling pathway.
UsesJK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).[Cayman Chemical]
Biological ActivityPotent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC 50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI 50 = 3 - 21 nM) and in human xenografts in vivo . Inhibits alcohol dehydrogenase 7 (Adh7) (IC 50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro .
storage+4°C
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Preparation Products And Raw materials
Tag:N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine(315703-52-7) Related Product Information
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