Danoprevir

Danoprevir Suppliers list

Company Name:	Wuhan Topule Biopharmaceutical Co., Ltd
Tel:	+8618327326525
Email:	masar@topule.com
Products Intro:	Product Name:RG7227 CAS:850876-88-9 Purity:0.95 Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing

Company Name:	Biochempartner
Tel:	0086-13720134139
Email:	candy@biochempartner.com
Products Intro:	Product Name:Danoprevir CAS:850876-88-9 Purity:98% HPLC LCMS Package:10G;20G

Company Name:	CONIER CHEM AND PHARMA LIMITED
Tel:	+8618523575427
Email:	sales@conier.com
Products Intro:	Product Name:danoprevir CAS:850876-88-9 Purity:0.99 Package:1kg

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354 +1-00000000000
Email:	marketing@targetmol.com
Products Intro:	Product Name:Danoprevir CAS:850876-88-9 Purity:99.52% Package:1mg;57USD\|5mg;139USD\|10mg;247USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	Career Henan Chemica Co
Tel:	+86-0371-86658258 +8613203830695
Email:	laboratory@coreychem.com
Products Intro:	Product Name:Danoprevir CAS:850876-88-9 Purity:0.99， AD68

Danoprevir manufacturers

The Synthetic method of Danoprevir
Danoprevir is an orally administered hepatitis C virus (HCV) NS3 protease inhibitor and recently approved in China for the tre....
Dec 20，2023

Danoprevir Basic information

Product Name:	Danoprevir
Synonyms:	RG7227, ITMN-191, RO5190591;4-Fluoro-1,3-dihydro-2H-isoindole-2-carboxylic acid (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester;ITMN-191;Danoprevir(ITMN-191);2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester;dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester Danoprevir (ITMN-191);Danoprevir, >=98%;Itmn-191 Danoprevir
CAS:	850876-88-9
MF:	C35H46FN5O9S
MW:	731.83
EINECS:
Product Categories:	Inhibitor;Inhibitors;Coronavirus
Mol File:	850876-88-9.mol

Danoprevir Chemical Properties

Melting point	>165°C (dec.)
density	1.41
storage temp.	-20°C Freezer
solubility	Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	4.43±0.60(Predicted)
color	White to Pale Beige
InChIKey	ZVTDLPBHTSMEJZ-AIYSODCISA-N
SMILES	C1C2=C(C(F)=CC=C2)CN1C(O[C@H]1CN2C(=O)[C@@H](NC(OC(C)(C)C)=O)CCCCCC=C[C@]3([H])C[C@@]3(C(NS(C3CC3)(=O)=O)=O)NC(=O)[C@]2([H])C1)=O \|t:33\|

Safety Information

MSDS Information

Danoprevir Usage And Synthesis

Description	Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC₅₀ = 1 nM), a serine protease essential for HCV replication. It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 μM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC₅₀s = 0.2-0.4 nM) as well as 2b and 3a (IC₅₀s = 1.6 and 3.5 nM, respectively) in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC₅₀ = 1.8 nM).
Uses	Danoprevir is a selective and potent inhibitor of Hepatitis C virus.
target	HCV NS3/4A protease

Danoprevir Preparation Products And Raw materials

Raw materials

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