3-[[4-[2-[(3-氯苯基)氨基]-4-嘧啶基]-2-吡啶基]氨基]-1-丙醇
中文名称 | 3-[[4-[2-[(3-氯苯基)氨基]-4-嘧啶基]-2-吡啶基]氨基]-1-丙醇 |
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中文同义词 | 3-[[4-[2-[(3-氯苯基)氨基]-4-嘧啶基]-2-吡啶基]氨基]-1-丙醇;PKC抑制剂(CGP60474);3-((4-(2-((3-氯苯基)氨基)嘧啶-4-基)吡啶-2-基)氨基)丙-1-醇;CGP60474,CDK抑制剂 |
英文名称 | 3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol |
英文同义词 | CGP 60474;3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol;CS-506;3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol;CGP-60474;CGP 60474;1-Propanol, 3-[[4-[2-[(3-chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-;3-((4-(2-((3-Chlorophenyl)amino)pyrimidin-4-yl)pyridin-2-yl)amino)propan-1-ol |
CAS号 | 164658-13-3 |
分子式 | C18H18ClN5O |
分子量 | 355.82 |
EINECS号 | 200-258-5 |
相关类别 | 细胞周期;细胞生物学试剂 |
Mol文件 | 164658-13-3.mol |
结构式 | ![]() |
3-[[4-[2-[(3-氯苯基)氨基]-4-嘧啶基]-2-吡啶基]氨基]-1-丙醇 性质
熔点 | 144-147℃ |
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沸点 | 630.6±65.0 °C(Predicted) |
密度 | 1.356 |
储存条件 | 2-8°C(protect from light) |
溶解度 | 溶于二甲基亚砜 |
形态 | 粉末 |
酸度系数(pKa) | 14.93±0.10(Predicted) |
颜色 | 浅黄至黄色 |
CDK1-Cyclin B 26 nM (IC 50 ) |
CDK2/cyclinE 3 nM (IC 50 ) |
cdk2/cyclin A 4 nM (IC 50 ) |
CDK4/cyclin D 216 nM (IC 50 ) |
Cdk5/p25 10 nM (IC 50 ) |
CDK7/cyclin H 200 nM (IC 50 ) |
CDK9/cycT 13 nM (IC 50 ) |
PKC
|
CGP60474 (Compound A) is a potent VEGFR-2 inhibitor, with an IC 50 of 84 nM. CGP60474 is also a PKC inhibitor, with competitive kinetics relative to ATP.
CGP-60474 (10 mg/kg; i.p.) inhibits the IL-6 level and increases the survival rate in the LPS endotoxemia model.
Animal Model: | C57Bl/6 mice (LPS endotoxemia model) |
Dosage: | 10 mg/kg |
Administration: | I.p. |
Result: | Had a higher survival rate. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-11009 | 3-[[4-[2-[(3-氯苯基)氨基]-4-嘧啶基]-2-吡啶基]氨基]-1-丙醇 CGP60474 | 164658-13-3 | 5mg | 1100元 |
2024/08/19 | HY-11009 | 3-[[4-[2-[(3-氯苯基)氨基]-4-嘧啶基]-2-吡啶基]氨基]-1-丙醇 CGP60474 | 164658-13-3 | 10mM * 1mLin DMSO | 1210元 |