N-[4-氯-2-[(1,3-二氢-1,3-二氧代-2H-异吲哚-2-基)甲基]苯基]-2-羟基苯甲酰胺
中文名称 | N-[4-氯-2-[(1,3-二氢-1,3-二氧代-2H-异吲哚-2-基)甲基]苯基]-2-羟基苯甲酰胺 |
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中文同义词 | N-[4-氯-2-[(1,3-二氢-1,3-二氧代-2H-异吲哚-2-基)甲基]苯基]-2-羟基苯甲酰胺;化合物 T10881;CPPHA,MGLU1和MGLU5受体的正变构调节剂 |
英文名称 | N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide |
英文同义词 | N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide;N-[4-Chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide;N-[4-Chloro-2-(phthalimidomethyl)phenyl]salicylamide;CPPHA;N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide;Benzamide, N-[4-chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxy- |
CAS号 | 693288-97-0 |
分子式 | C22H15ClN2O4 |
分子量 | 406.82 |
EINECS号 | |
相关类别 | G蛋白偶联受体&G蛋白 |
Mol文件 | 693288-97-0.mol |
结构式 | ![]() |
N-[4-氯-2-[(1,3-二氢-1,3-二氧代-2H-异吲哚-2-基)甲基]苯基]-2-羟基苯甲酰胺 性质
沸点 | 539.7±50.0 °C(Predicted) |
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密度 | 1.505 |
储存条件 | -20°C |
溶解度 | 二甲基亚砜:>20mg/mL |
形态 | 固体 |
酸度系数(pKa) | 8.24±0.30(Predicted) |
颜色 | 浅黄至黄色 |
mGlu5 Receptor
|
CPPHA alone has no agonist activity.
CPPHA causes concentration-dependent potentiation of the response of human mGluR5 CHO cells to agonists.
CPPHA potentiates threshold response to glutamate in fluorometric Ca
2+
assays 7- to 8-fold with EC
50
values in the 400 to 800 nM range.
CPPHA (20 μM; 15 minutes) potentiates the response to a subthreshold concentration of DHPG (HY-12598A) on ERK and cyclic-AMP responsive element-binding protein (CREB) activity, as well as NMDA receptor subunit NR1 phosphorylation in cortical and hippocampal slices.
Western Blot Analysis
Cell Line: | Rat hippocampal cells |
Concentration: | 20 μM |
Incubation Time: | 15 minutes |
Result: | Potentiated the DHPG (20 μM)-induced increase in phosphorylation of ERK and CREB, approaching levels seen with 100 μM DHPG alone. |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-14612 | N-[4-氯-2-[(1,3-二氢-1,3-二氧代-2H-异吲哚-2-基)甲基]苯基]-2-羟基苯甲酰胺 CPPHA | 693288-97-0 | 10mM * 1mLin DMSO | 770元 |
2024/04/30 | HY-14612 | N-[4-氯-2-[(1,3-二氢-1,3-二氧代-2H-异吲哚-2-基)甲基]苯基]-2-羟基苯甲酰胺 CPPHA | 693288-97-0 | 10mg | 1300元 |