GW1929
中文名称 | GW1929 |
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中文同义词 | N-(2-苯甲酰基苯基)-O-[2-(甲基-2-吡啶基氨基)乙基]-L-酪氨酸;GW1929 CALBIOCHEM |
英文名称 | GW1929 |
英文同义词 | GW1929;GW1929 HYDRATE;N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrate;(2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid;(S)-2-(2-Benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid;GW 1929 hydrochloride;N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosinehydrochloride;N-(2-BENZOYLPHENYL)-O-[2-(METHYL-2-PYRIDINYLAMINO)ETHYL]-L-TYROSINE |
CAS号 | 196808-24-9 |
分子式 | C30H29N3O4 |
分子量 | 495.57 |
EINECS号 | |
相关类别 | 细胞周期;小分子;Intracellular receptor |
Mol文件 | 196808-24-9.mol |
结构式 | ![]() |
GW1929 性质
沸点 | 749.2±60.0 °C(Predicted) |
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密度 | 1.264±0.06 g/cm3(Predicted) |
储存条件 | Desiccate at +4°C |
溶解度 | 二甲基亚砜:20 毫克/毫升 |
形态 | 固体 |
酸度系数(pKa) | 3.91±0.10(Predicted) |
颜色 | 粘黄色 |
InChIKey | QTQMRBZOBKYXCG-MHZLTWQESA-N |
PPAR-γ 8.56 (pEC 50 , Human PPAR-γ) |
GW1929 is a potent PPAR-γ activator, with pK i s of 8.84, < 5.5, and < 6.5 for human PPAR-γ, PPAR-α, and PPAR-δ, and pEC 50 s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. GW1929 (10 μM) inhibits TBBPA-induced caspase-3 increase and TBBPA-stimulated LDH release in neocortical cell cultures.
GW1929 (0.5, 1, 5 mg/kg, p.o.) highly decreases nonfasted plasma glucose levels in Zucker diabetic fatty (ZDF) rats after treatment for 14 days, and possesses antilipolytic efficacy. GW1929 (1, 5 mg/kg, p.o.) increases glucose-stimulated insuline secretion of β-cell in ZDF rats.
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-15655 | N-(2-苯甲酰基苯基)-O-[2-(甲基-2-吡啶基氨基)乙基]-L-酪氨酸 GW1929 | 196808-24-9 | 5 mg | 950元 |
2024/04/30 | HY-15655 | N-(2-苯甲酰基苯基)-O-[2-(甲基-2-吡啶基氨基)乙基]-L-酪氨酸 GW1929 | 196808-24-9 | 10mM * 1mLin DMSO | 1045元 |