ChemicalBook > Product Catalog >Organic Chemistry >Phosphines >LL-37

LL-37

LL-37 Suppliers list
Company Name: Shanghai Affida new material science and technology center
Tel: +undefined15081010295
Email: admin@oudaxin.com
Products Intro: Product Name:LL37
CAS:154947-66-7
Purity:99 Package:1Box;|10Box;|20Box Remarks:5KG;1KG;25KG
Company Name: Sichuan Tai Hui Biotechnology Co., Ltd
Tel: +86-18224031330 +86-18081096520
Email: 404435307@qq.com
Products Intro: Product Name:LL-37
CAS:154947-66-7
Purity:98%or99% Package:1g
Company Name: Hebei Weimiao Import and Export Trade Co., Ltd.
Tel: +undefined19948166995
Email: sale01@hbweimiao.com
Products Intro: Product Name:LL-37
CAS:154947-66-7
Purity:99% Package:1Box;200USD|5Box;190USD|10Box;180USD
Company Name: hebei hongtan Biotechnology Co., Ltd
Tel: +86-86-1913198-3935 +8617331935328
Email: sales03@chemcn.cn
Products Intro: Product Name:LL 37
CAS:154947-66-7
Purity:98% Package:1box;30USD
Company Name: CONTIDE BIOTECH CO.,LTD
Tel: +852-53358525
Email: xena@healthtide-api.com
Products Intro: Product Name:LL37
CAS:154947-66-7
Purity:99% Package:1G;0.00;USD Remarks:g

LL-37 manufacturers

  • LL-37
  • LL-37 pictures
  • $1.00 / 1g
  • 2024-08-03
  • CAS:154947-66-7
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 100kg
  • LL37
  • LL37 pictures
  • $0.00 / 1G
  • 2024-08-02
  • CAS:154947-66-7
  • Min. Order: 1G
  • Purity: 99%
  • Supply Ability: 5kg
  • LL-37
  • LL-37 pictures
  • $85.00 / 1box
  • 2024-08-01
  • CAS:154947-66-7
  • Min. Order: 1box
  • Purity: 99.9%
  • Supply Ability: 2000box
LL-37 Basic information
Structure
Product Name:LL-37
Synonyms:Antibacterial Protein LL-37 (huMan), LL37, CAMP;H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH;Antibacterial Protein LL-37 (human);LL-37 (trifluoroacetate salt);LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES;Cathelicidin LL 37 (human);LL-37, LL37, CAMP;LL-37 human acetate
CAS:154947-66-7
MF:C205H340N60O53
MW:0
EINECS:211-519-9
Product Categories:
Mol File:Mol File
LL-37 Structure
LL-37 Chemical Properties
solubility Water: 1 mg/ml
form A lyophilized powder
color White to off-white
Water Solubility Soluble to 1 mg/ml in water
InChIKeyPOIUWJQBRNEFGX-XAMSXPGMSA-N
Safety Information
MSDS Information
LL-37 Usage And Synthesis
StructureThe structure of LL-37 in SDS micelles is composed of a curved amphipathic helix-bend-helix motif spanning residues 2–31 followed by a disordered C-terminal tail. The helical bend is located between residues Gly-14 and Glu-16. Similar chemical shifts and 15N nuclear Overhauser effect (NOE) patterns of the peptide in complex with di octanoyl phosphatidylglycerol (D8PG) micelles indicate a similar structure. The aromatic rings of Phe-5, Phe-6, Phe-17, and Phe-27 of LL-37, as well as arginines, showed intermolecular NOE cross-peaks with D8PG, providing direct evidence for the association of the entire amphipathic helix with anionic lipid micelles. The structure of LL-37 serves as a model for understanding the structure and function relationship of homologous primate cathelicidins[5].
DescriptionLL-37, Human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.
UsesL 37 (human) is a 37 amino acid host defense peptide originating from the C-terminal of the human cathelicidin antimicrobial peptide (CAMP, hCAP18). This peptide possesses antimicrobial, antitumor, antiviral, and immunomodulatory properties, along with physiological functions in chemotaxis, wound healing, and angiogenesis. Beyond its antimicrobial capabilities, LL 37 (human) influences various pathways in autoimmune and inflammatory diseases, playing a role in the development of lupus, rheumatoid arthritis, and atherosclerosis. As a binding partner to Aβ42, the expression of LL 37 (human) affects the onset and progression of Alzheimer's disease. Additionally, LL 37 has a notable role in human cancer, promoting tumorigenic effects in ovarian, lung, breast, prostate, pancreatic cancers, and malignant melanoma.
OriginMammalian AMPs belong to the defensin and cathelicidin families. So far, there is a unique cathelicidin peptide found in 1995 and called human cationic antimicrobial peptide (hCAP18). Its active part starts with double leucine and consists of 37-amino acids at the C-terminus, so which is called LL-37.
benefitsLL-37 is an important part of the human immune system, which can resist various pathogens. A plethora of experiments have demonstrated that it has the multifunctional effects of immune regulation, in addition to antimicrobial activity.  Significantly boosts immune function; Fights inflammation; Prevents cancer progression; Accelerates wound healing; Lowers the risk of heart disease; Prevents lung injury; Promotes bone repair.

Biological ActivityLL 37 is an antimicrobial peptide derivative of human cathelicidin. Induces FPRL1-mediated chemotaxis of human neutrophils, monocytes and T cells in vitro. Promotes wound healing following skin-targeted electroporation of a plasmid encoding hCAP-18/LL-37 in mice. LL 37 reduces SARS-CoV-2 infection by blocking the receptor binding domain of the S1 spike protein (Kd = 11.2 nM) and by binding to ACE2 (Kd = 25.5.nM). LL 37 inhibits SARS-CoV-2 pseudovirion infection (IC50 = 4.74 μg/mL) in vitro and in vivo. Also triggers apoptosis in colon cancer cells. Cell permeable.
Side effectsLL-37 side effects are very uncommon. LL-37 induced apparent rosacea symptoms, erythema, and telangiectasia on the skin. Side effects associated with LL-37 may include the following:
Increased inflammation
Induction of autoimmune disease
Depression
Damage to sperm surface membranes
storageStore at -20°C
References [1]Kahlenberg and Kaplan (2013) Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. J. Immunol. 191(10) 4895 PMID: 24185823
[2]Bandurska et al (2015) Unique features of human cathelicidin LL‐37. BioFactors 41 289 PMID: 26434733
[3]Chen et al (2018) Roles and Mechanisms of Human Cathelicidin LL-37 in Cancer. Cell Physiol.Biochem. 47 1060 PMID: 29843147
[4]Vierthaler et al (2020) Fluctuating role of antimicrobial peptide hCAP18/LL?37 in oral tongue dysplasia and carcinoma. Oncol. Rep. 44 325 PMID: 32627035
[5]Wang, Guangshun. “Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles.” The Journal of Biological Chemistry 283 47 (2008): 32637–43.
LL-37 Preparation Products And Raw materials
Tag:LL-37(154947-66-7) Related Product Information
AC-MURAMYL-ALA-GLU-NH2 andropin N-(9-Fluorenylmethoxycarbonyloxy)succinimide GAP 26 Prezatide copper acetate ADRENOMEDULLIN (16-31) (HUMAN, PIG) Thymosin α1 Acetyl Octapeptide-3 N-BOC-L-leucylglycyl-arginine-p-nitroanilide hydrochloride H-LEU-ARG-ALA-HIS-ALA-VAL-ASP-VAL-ASN-GLY-NH2 Degarelix Palmitoyl Pentapeptide ADRENOMEDULLIN (HUMAN) Argireline Plecanatide Amyloid β-Peptide (1-42) (human) Dulaglutide Polybia-MP1 trifluoroacetate salt