SDZ 220-581 (hydrochloride)

SDZ 220-581 (hydrochloride) Suppliers list
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Products Intro: Product Name:SDZ 220-581 hydrochloride
CAS:179411-93-9
Purity:98.00% Package:1 mL * 10mM (in DMSO);10 mg;100 mg;200 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:SDZ 220-581 hydrochloride
CAS:179411-93-9
Purity:0.97 Package:mgs,gs,kgs Remarks:A919330
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Products Intro: Product Name:SDZ 220-581 (hydrochloride)
CAS:179411-93-9
Purity:>98% Package:1395RMB/10mg
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Products Intro: Product Name:SDZ 220-581 (hydrochloride)
CAS:179411-93-9
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
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Products Intro: Product Name:SDZ 220-581 (hydrochloride)
CAS:179411-93-9
Purity:98% Package:5952RMB/50mg
SDZ 220-581 (hydrochloride) Basic information
Product Name:SDZ 220-581 (hydrochloride)
Synonyms:SDZ 220-581 (hydrochloride);(S)-alpha-Amino-2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-propanoic acid hydrochloride;(S)-α-Amino-2-chloro-5-(phosphonomethyl)[1,1-biphenyl]-3-propanoic acid hydrochloride;SDZ 220-581 hydrochloride >=98% (HPLC);SDZ 220 581 hydrochloride,SDZ 220581 hydrochloride
CAS:179411-93-9
MF:C16H18Cl2NO5P
MW:406.2
EINECS:
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Mol File:179411-93-9.mol
SDZ 220-581 (hydrochloride) Structure
SDZ 220-581 (hydrochloride) Chemical Properties
storage temp. room temp
solubility DMSO: soluble5mg/mL, clear (warmed)
form powder
color white to beige
optical activity[α]/D -5 to -8°, c = 1 in 1 M HCl
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
WGK Germany 3
MSDS Information
SDZ 220-581 (hydrochloride) Usage And Synthesis
Biological Activitysdz 220-581 hydrochloride is a potent and competitive antagonist of nmda receptor with pki value of 7.7 [1].sdz 220-581 is a biphenyl-ap7-derivative. it is potent both in vitro and in vivo. sdz 220-581 binds with high affinity to the recognition site of nmda receptor. it does not bind to the strychnine-insensitive glycine site or the mk-801 site within the nmda receptor. in addition, sdz 220-581 shows no effect on a variety of other binding assays such as for dopamine, serotonin and adenosine [1].in the in vivo assay, the administration of sdz 220-581 protects the mice against the maximal electroshock-induced seizures (mes). in the rat mes model, sdz 220-581 also shows potent efficacy. moreover, sdz 220-581 can protect brain against quinolinic acid induced neuronal degeneration in rat. furthermore, a dose of 1.25mg/kg sdz 220-581 markedly reduces the cerebral infarct size in the focal cerebral ischemia model in rat [2].
references[1] urwyler et al .biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive n-methyl-d-aspartate receptor antagonists - ii. pharmacological characterization in vivo. neuropharmacology 1996, 35 655.
[2] urwyler s, campbell e, fricker g, et al. biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitiven-methyl-d-aspartate receptor antagonists—ii. pharmacological characterization in vivo[j]. neuropharmacology, 1996, 35(6): 655-669.
SDZ 220-581 (hydrochloride) Preparation Products And Raw materials
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