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Haoyuan Chemexpress Co., Ltd.
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Product Name:SDZ 220-581 (hydrochloride)
CAS:179411-93-9
Purity:>98% Package:1395RMB/10mg
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SPIRO PHARMA
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Product Name:SDZ 220-581 (hydrochloride)
CAS:179411-93-9
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
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Guangzhou QiYun Biotechnology Co., Ltd.
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| Products Intro: |
Product Name:SDZ 220-581 (hydrochloride)
CAS:179411-93-9
Purity:98% Package:5952RMB/50mg
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| | SDZ 220-581 (hydrochloride) Basic information |
| Product Name: | SDZ 220-581 (hydrochloride) | | Synonyms: | SDZ 220-581 (hydrochloride);(S)-alpha-Amino-2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-propanoic acid hydrochloride;(S)-α-Amino-2-chloro-5-(phosphonomethyl)[1,1-biphenyl]-3-propanoic acid hydrochloride;SDZ 220-581 hydrochloride >=98% (HPLC);SDZ 220 581 hydrochloride,SDZ 220581 hydrochloride;SDZ 220-581 hydrochloride, SDZ220-581, SDZ-220-581 | | CAS: | 179411-93-9 | | MF: | C16H18Cl2NO5P | | MW: | 406.2 | | EINECS: | | | Product Categories: | | | Mol File: | 179411-93-9.mol |  |
| | SDZ 220-581 (hydrochloride) Chemical Properties |
| storage temp. | room temp | | solubility | DMSO: soluble5mg/mL, clear (warmed) | | form | powder | | color | white to beige | | optical activity | [α]/D -5 to -8°, c = 1 in 1 M HCl |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| | SDZ 220-581 (hydrochloride) Usage And Synthesis |
| Uses | SDZ 220-581 hydrochloride is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7[1]. | | Biological Activity | sdz 220-581 hydrochloride is a potent and competitive antagonist of nmda receptor with pki value of 7.7 [1].sdz 220-581 is a biphenyl-ap7-derivative. it is potent both in vitro and in vivo. sdz 220-581 binds with high affinity to the recognition site of nmda receptor. it does not bind to the strychnine-insensitive glycine site or the mk-801 site within the nmda receptor. in addition, sdz 220-581 shows no effect on a variety of other binding assays such as for dopamine, serotonin and adenosine [1].in the in vivo assay, the administration of sdz 220-581 protects the mice against the maximal electroshock-induced seizures (mes). in the rat mes model, sdz 220-581 also shows potent efficacy. moreover, sdz 220-581 can protect brain against quinolinic acid induced neuronal degeneration in rat. furthermore, a dose of 1.25mg/kg sdz 220-581 markedly reduces the cerebral infarct size in the focal cerebral ischemia model in rat [2]. | | in vivo | SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action[1]. | Animal Model: | Male OF-l mice (18-26 g)[1] | | Dosage: | 3.2 mg/kg, 10 mg/kg, 32 mg/kg | | Administration: | Oral administration; for 24 hours | | Result: | Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration.
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| | references | [1] urwyler et al .biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive n-methyl-d-aspartate receptor antagonists - ii. pharmacological characterization in vivo. neuropharmacology 1996, 35 655.
[2] urwyler s, campbell e, fricker g, et al. biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitiven-methyl-d-aspartate receptor antagonists—ii. pharmacological characterization in vivo[j]. neuropharmacology, 1996, 35(6): 655-669. |
| | SDZ 220-581 (hydrochloride) Preparation Products And Raw materials |
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