(S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐
| 中文名称 | (S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐 |
|---|---|
| 中文同义词 | (S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐;化合物 T12889L |
| 英文名称 | SDZ 220-581 (hydrochloride) |
| 英文同义词 | SDZ 220-581 (hydrochloride);(S)-alpha-Amino-2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-propanoic acid hydrochloride;(S)-α-Amino-2-chloro-5-(phosphonomethyl)[1,1-biphenyl]-3-propanoic acid hydrochloride;SDZ 220-581 hydrochloride >=98% (HPLC);SDZ 220 581 hydrochloride,SDZ 220581 hydrochloride |
| CAS号 | 179411-93-9 |
| 分子式 | C16H18Cl2NO5P |
| 分子量 | 406.2 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 179411-93-9.mol |
| 结构式 | ![(S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐 结构式](CAS/20150408/GIF/179411-93-9.gif) |
(S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐 性质
| 储存条件 | room temp |
|---|---|
| 溶解度 | DMSO：可溶5mg/mL，澄清（加热） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 旋光性 (optical activity) | [α]/D -5 to -8°, c = 1 in 1 M HCl |
SDZ 220-581 hydrochloride 是一种口服生物利用度，有效的竞争性的 NMDA 受体拮抗剂，pKi 值为 7.7。
pKi: 7.7 ( NMDA receptor )
SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action.
| Animal Model: | Male OF-l mice (18-26 g) |
| Dosage: | 3.2 mg/kg, 10 mg/kg, 32 mg/kg |
| Administration: | Oral administration; for 24 hours |
| Result: | Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-13059B | SDZ 220-581 hydrochloride | 5 mg | 871元 | |
| 2024/04/30 | HY-13059B | (S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐 SDZ 220-581 hydrochloride | 179411-93-9 | 10mg | 1395元 |