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| | NS 3623 Basic information |
| Product Name: | NS 3623 | | Synonyms: | NS 3623;1-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea;N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea;1-(4-Bromo-2-(1H-tetrazol-5-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea;channels,NS 3623,midmyocardial,cardiomyocytes,current,ion,NS3623,Potassium Channel,canine,Potassium,KcsA,Inhibitor,inhibit,cells,Antiarrhythmic,effect,NS-3623;Urea, N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]- | | CAS: | 343630-41-1 | | MF: | C15H10BrF3N6O | | MW: | 427.18 | | EINECS: | | | Product Categories: | Agonist, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 343630-41-1.mol |  |
| | NS 3623 Chemical Properties |
| density | 1.759±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble to 100 mM in DMSO | | form | Powder | | pka | 3.95±0.10(Predicted) | | color | White to off-white |
| | NS 3623 Usage And Synthesis |
| Uses | NS 3623 selectively activates the human ether-a-go-go related gene (hERG) potassium channel which mediates the repolarizing cardiac current IKr. NS 3623 an IKr agonist, cause QT interval prolongation, increasing the risk of dangerous ventricular fibrillations, eventually leading to sudden cardiac death. | | storage | Store at +4°C |
| | NS 3623 Preparation Products And Raw materials |
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