- 10-Nitrocamptothecin
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- $1.10 / 1g
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2022-05-24
- CAS:86639-62-5
- Min. Order: 1g
- Purity: 99.0% Min
- Supply Ability: 100 Tons
- 9-Nitrocamptothecin
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- $0.10 / 1KG
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2019-12-25
- CAS:86639-62-5
- Min. Order: 1KG
- Purity: 95%-99%
- Supply Ability: 1kg; 50kg; 500kg
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| | 10-Nitrocamptothecin Basic information |
| Product Name: | 10-Nitrocamptothecin | | Synonyms: | RUBETICAN;CAMPTOTHECIN, 9-NITRO-20(S)-;9-NITRO-CPT;4α-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;9-Nitro-20(S)-camptothecine;(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(S)-4-Ethyl-4-hydroxy-9-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-di | | CAS: | 86639-62-5 | | MF: | C20H15N3O6 | | MW: | 393.35 | | EINECS: | | | Product Categories: | Natural Anti-cancer Medical Materials and It's Derivatives | | Mol File: | 86639-62-5.mol |  |
| | 10-Nitrocamptothecin Chemical Properties |
| Boiling point | 827.4±65.0 °C(Predicted) | | density | 1.63±0.1 g/cm3(Predicted) | | pka | 11.17±0.20(Predicted) |
| | 10-Nitrocamptothecin Usage And Synthesis |
| Uses | Whether cells can divide depends on the two key points of entering S phase and M phase. Studies have found that 10-Nitrocamptothecin can induce apoptosis. After administration, both S phase and G2M phase of cell growth are delayed. Inhibition occurred throughout the cell cycle and was found to be dose- and time-dependent. | | Definition | ChEBI: Rubitecan is a pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin. It has a role as an antineoplastic agent, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and a prodrug. It is a pyranoindolizinoquinoline, a C-nitro compound, a semisynthetic derivative, a tertiary alcohol and a delta-lactone. |
| | 10-Nitrocamptothecin Preparation Products And Raw materials |
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