内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ)
| 中文名称 | 内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ) |
|---|---|
| 中文同义词 | 内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ);四(4-羧基苯基)卟啉氯化锰(Ⅲ);5,10,15,20-四(4-羧基苯基)-21H,23H-卟吩]氯化锰(III);锰酸盐(4-),氯[[4,4',4',4''-(21H,23H-卟啉-5,10,15,20-四Α-Κ21,Κ222,ΚN23,Κ244)TETRAKIS[BENZOATO]](6-)]-,氢气(1:4),(SP-5-12)-;MNTBAP氯化物;化合物MN(III)TBAP |
| 英文名称 | Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride |
| 英文同义词 | Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride;Manganese(III) meso-tetra(4-carboxyphenyl)porphine chloride;Mn(III)TBAP (chloride);5,10,15,20-Tetrakis(4-carboxyphenyl)porphyrin-Mn(III) chloride (MnTBAP);5,10,15,20-Tetrakis(4-carboxyphenyl)-21H,23H-porphine]manganese(III) chloride |
| CAS号 | 55266-18-7 |
| 分子式 | C48H28ClMnN4O8 |
| 分子量 | 879.148969 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 55266-18-7.mol |
| 结构式 |  |
内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ) 性质
| 储存条件 | -20C |
|---|---|
| 溶解度 | 溶于0.1M NaOH |
| 形态 | 棕色固体 |
| 颜色 | 黑色 |
| 稳定性 | 可在-20°下的0.1MNaOH溶液保存长达1个月。 |
MnTBAP (55266-18-7) 是一种超氧化物歧化酶 (SOD) 模拟物，可用作过氧亚硝酸盐清除剂，但不清除一氧化氮。MnTBAP chloride 是一种超氧化物歧化酶 (SOD) 模拟物和过氧亚硝酸盐清除剂。MnTBAP chloride 是一种锰卟啉配合物，具有抗氧化性能。MnTBAP chloride 通过上调 BMPR-II 和抑制 NFκB 信号传导介导抗炎作用。MnTBAP chloride 具有抗氧化性能，具有用于研究慢性肾脏疾病 (CKDs) 纤维化反应的潜力。
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NFκB
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MnTBAP chloride (pretreated 1.14 μM before TGF-β1 of 10 ng/mL) partially but significantly restores E-cadherin reduction and suppresses the induction of α-SMA and vimentin in immortalized mouse proximal tubular cells (mPTCs).
MnTBAP chloride (50 μM; 6 hours) increases BMPR-II mRNA by 1.3-fold at 2 h, but does not affect protein expression of BMPR-II during a time course of 16 h in HUVECs. MnTBAP chloride increases phosphorylation of Smad 1/5, suggesting modulation of the BMP signaling pathway.
MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice.
| Animal Model: | C57BL/6J mice with 5/6 nephrectomy (Nx) |
| Dosage: | 10 mg/kg |
| Administration: | IP; three times per week for twelve weeks |
| Result: | Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys. |