内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ)
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- CAS号:
- 55266-18-7
- 英文名:
- Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride
- 英文别名:
- Mn(III)TBAP (chloride);Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride;Manganese(III) meso-tetra(4-carboxyphenyl)porphine chloride;5,10,15,20-Tetrakis(4-carboxyphenyl)porphyrin-Mn(III) chloride (MnTBAP);5,10,15,20-Tetrakis(4-carboxyphenyl)-21H,23H-porphine]manganese(III) chloride
- 中文名:
- 内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ)
- 中文别名:
- MNTBAP氯化物;化合物MN(III)TBAP;四(4-羧基苯基)卟啉氯化锰(Ⅲ);内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ);5,10,15,20-四(4-羧基苯基)-21H,23H-卟吩]氯化锰(III);锰酸盐(4-),氯[[4,4',4',4''-(21H,23H-卟啉-5,10,15,20-四Α-Κ21,Κ222,ΚN23,Κ244)TETRAKIS[BENZOATO]](6-)]-,氢气(1:4),(SP-5-12)-
- CBNumber:
- CB02709192
- 分子式:
- C48H28ClMnN4O8
- 分子量:
- 879.148969
- MOL File:
- 55266-18-7.mol
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内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ)化学性质
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储存条件:
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-20C
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溶解度:
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Soluble in 0.1M NaOH
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形态:
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Brown solid
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颜色:
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Black
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in 0.1M NaOH may be stored at -20° for up to 1 month.
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内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ)性质、用途与生产工艺
MnTBAP (55266-18-7) 是一种超氧化物歧化酶 (SOD) 模拟物，可用作过氧亚硝酸盐清除剂，但不清除一氧化氮。
MnTBAP chloride 是一种超氧化物歧化酶 (SOD) 模拟物和过氧亚硝酸盐清除剂。MnTBAP chloride 是一种锰卟啉配合物，具有抗氧化性能。MnTBAP chloride 通过上调 BMPR-II 和抑制 NFκB 信号传导介导抗炎作用。MnTBAP chloride 具有抗氧化性能，具有用于研究慢性肾脏疾病 (CKDs) 纤维化反应的潜力。
MnTBAP chloride (pretreated 1.14 μM before TGF-β1 of 10 ng/mL) partially but significantly restores E-cadherin reduction and suppresses the induction of α-SMA and vimentin in immortalized mouse proximal tubular cells (mPTCs).
MnTBAP chloride (50 μM; 6 hours) increases BMPR-II mRNA by 1.3-fold at 2 h, but does not affect protein expression of BMPR-II during a time course of 16 h in HUVECs. MnTBAP chloride increases phosphorylation of Smad 1/5, suggesting modulation of the BMP signaling pathway.
MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice.
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Animal Model:
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C57BL/6J mice with 5/6 nephrectomy (Nx)
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Dosage:
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10 mg/kg
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Administration:
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IP; three times per week for twelve weeks
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Result:
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Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.
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内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ)
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上游原料
下游产品
内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ)
生产厂家
55266-18-7, 内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ) 相关搜索:
- 药靶配体
- 化合物MN(III)TBAP
- MNTBAP氯化物
- 锰酸盐(4-),氯[[4,4',4',4''-(21H,23H-卟啉-5,10,15,20-四Α-Κ21,Κ222,ΚN23,Κ244)TETRAKIS[BENZOATO]](6-)]-,氢气(1:4),(SP-5-12)-
- 5,10,15,20-四(4-羧基苯基)-21H,23H-卟吩]氯化锰(III)
- 四(4-羧基苯基)卟啉氯化锰(Ⅲ)
- 内消旋-四(4 - 羧基苯基)卟啉氯化锰(Ⅲ)
- 55266-18-7
- 5,10,15,20-Tetrakis(4-carboxyphenyl)-21H,23H-porphine]manganese(III) chloride
- 5,10,15,20-Tetrakis(4-carboxyphenyl)porphyrin-Mn(III) chloride (MnTBAP)
- Mn(III)TBAP (chloride)
- Manganese(III) meso-tetra(4-carboxyphenyl)porphine chloride
- Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride