1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione manufacturers
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| | 1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione Basic information |
| Product Name: | 1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione | | Synonyms: | 1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione;1-(2-chloro-1-hydroxy-3-(quinolin-6-yl)propyl)pyrrolidine-2,5-dione;2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione;2,5-Pyrrolidinedione, 1-[2-chloro-1-hydroxy-3-(6-quinolinyl)propyl]-;1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidin... | | CAS: | 1197377-31-3 | | MF: | C16H15ClN2O3 | | MW: | 318.75 | | EINECS: | 811-462-5 | | Product Categories: | | | Mol File: | 1197377-31-3.mol | ![1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione Structure](CAS/20150408/GIF/1197377-31-3.gif) |
| | 1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione Chemical Properties |
| Boiling point | 598.3±50.0 °C(Predicted) | | density | 1.434±0.06 g/cm3(Predicted) | | vapor pressure | 0-0Pa at 20-25℃ | | pka | 11.45±0.20(Predicted) | | InChI | InChI=1S/C16H15ClN2O3/c17-12(16(22)19-14(20)5-6-15(19)21)9-10-3-4-13-11(8-10)2-1-7-18-13/h1-4,7-8,12,16,22H,5-6,9H2 | | InChIKey | FUPWOFWDARMISK-UHFFFAOYSA-N | | SMILES | N1(C(O)C(Cl)CC2=CC=C3C(=C2)C=CC=N3)C(=O)CCC1=O | | LogP | 0.9 at 20℃ and pH7 |
| | 1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione Usage And Synthesis |
| Synthesis | A solution of 3-quinolin-6-ylpropanal in acetonitrile was cooled to 0° C before L-proline, benzoic acid, and N-chlorosuccinimide were added at 0° C. The reaction mixture was stirred at 0° C for 3 h, and the resulting clear solution was allowed to warm to room temperature and stirred at RT for 18 h. The reaction mixture became a thick suspension, and LCMS showed the completion of the reaction. Ethyl acetate (EtOAc) was added to the reaction mixture, stirring at room temperature for 1 h. The solids were collected by filtration, washed with ethyl acetate, and dried under vacuum at 40-45° C to constant weight to afford 1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione as an off-white powder. yield: 65.![1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione](/NewsImg/2023-11-13/6383548140088645036596909.jpg "1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione") |
| | 1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione Preparation Products And Raw materials |
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