PIRONETIN
中文名称 | PIRONETIN |
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中文同义词 | 化合物 T16543 |
英文名称 | PIRONETIN |
英文同义词 | PIRONETIN;2H-Pyran-2-one, 5-ethyl-5,6-dihydro-6-[(2R,3S,4R,5S,7E)-2-hydroxy-4-methoxy-3,5-dimethyl-7-nonen-1-yl]-, (5R,6R)- |
CAS号 | 151519-02-7 |
分子式 | C19H32O4 |
分子量 | 324.45 |
EINECS号 | |
相关类别 | 标准品;Antibiotic |
Mol文件 | 151519-02-7.mol |
结构式 |
PIRONETIN 性质
熔点 | 75-77 °C |
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沸点 | 473.1±40.0 °C(Predicted) |
密度 | 0.993±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二氯甲烷:可溶; DMSO:可溶;乙醇:可溶 |
形态 | 固体 |
酸度系数(pKa) | 14.28±0.20(Predicted) |
Microtubule
Pironetin (20-100 ng/mL; 24 hours; 3Y1 cells) treatment arrests the cell cycle progression at G2/M in 3Y1 cells.
Pironetin (1-10000 ng/mL; 3 days; HeLa, A2780 and K-NRK cells) treatment inhibits the cell proliferation.
IC
50
values against these cell lines are almost 10 ng/mL.
Cell Cycle Analysis
Cell Line: | 3Y1 cells |
Concentration: | 20 ng/mL, 50 ng/mL, 100 ng/mL |
Incubation Time: | 24 hours |
Result: | Arrested the cell cycle progression at G2/M in3Y1 cells. |
Cell Proliferation Assay
Cell Line: | HeLa, A2780 and K-NRK cells |
Concentration: | 1 ng/mL, 10 ng/mL, 100 ng/mL, 1000 ng/mL and 10000 ng/mL |
Incubation Time: | 3 days |
Result: | Inhibited the cell proliferation. |
Pironetin (0.78-6.25 mg/kg; intraperitoneal injection; daily; for 5 days; female CDF1-SLC mice) treatment shows a moderate antitumor effect, however, a severe weight loss is observed as a side effect.
Animal Model: | Female CDF1-SLC mice (10 weeks) injected with P388 murine leukemia cells |
Dosage: | 0.78 mg/kg, 1.56 mg/kg, 3.13 mg/kg, 6.25 mg/kg |
Administration: | Intraperitoneal injection; daily; for 5 days |
Result: | Showed a moderate antitumor effect. |
安全信息
海关编码 | 29419000 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-116446 | PIRONETIN Pironetin | 151519-02-7 | 1mg | 8800元 |