BFH772

BFH772 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:BFH772
CAS:890128-81-1
Purity:0.99 Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: factory@coreychem.com
Products Intro: Product Name:BFH772
CAS:890128-81-1
Purity:99.99% Package:1g;1USD
Company Name: SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel: +86-021-61551413 +8618813727289
Email: contact@trustwe.com
Products Intro: Product Name:BFH772
CAS:890128-81-1
Purity:98% Package:Package as requetsed
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:BFH772
CAS:890128-81-1
Purity:99.36% Package:2mg;38USD|5mg;60USD|10mg;105USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:BFH772
CAS:890128-81-1
Purity:99% Package:5KG;1KG Remarks:BFH772

BFH772 manufacturers

  • BFH772
  • BFH772 pictures
  • $38.00 / 2mg
  • 2024-11-19
  • CAS:890128-81-1
  • Min. Order:
  • Purity: 99.36%
  • Supply Ability: 10g
  • BFH772
  • BFH772 pictures
  • $1.00 / 1g
  • 2019-12-23
  • CAS:890128-81-1
  • Min. Order: 1g
  • Purity: 99.99%
  • Supply Ability: 200kg
BFH772 Basic information
Product Name:BFH772
Synonyms:BFH772;Bfh-722;CS-2412;BFH-772; BFH 772;1-Naphthalenecarboxamide, 6-[[6-(hydroxymethyl)-4-pyrimidinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-;6-((6-(Hydroxymethyl)pyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide;inhibit,BFH 772,VEGFR,BFH-772,BFH772,Vascular endothelial growth factor receptor,Inhibitor;BFH772, 10 mM in DMSO
CAS:890128-81-1
MF:C23H16F3N3O3
MW:439.39
EINECS:
Product Categories:
Mol File:890128-81-1.mol
BFH772 Structure
BFH772 Chemical Properties
Boiling point 541.2±50.0 °C(Predicted)
density 1.432±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form A crystalline solid
pka12.65±0.70(Predicted)
color White to off-white
Safety Information
MSDS Information
BFH772 Usage And Synthesis
DescriptionBFH772 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.0027 μM for the human receptor). It is selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s = 1.5, 1.7, and 1.1 μM, respectively), as well as 40-fold selective over B-RAF, RET, and Tie2. BFH772 inhibits VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = <0.01 nM). It inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice when administered at doses of 1 and 3 mg/kg per day. BFH772 (3 mg/kg per day) inhibits primary tumor and metastasis growth in a B16 melanoma mouse model.
in vitrobfh772 was highly effective at targeting vegfr2 kinase, however, lost 500-fold potency on flk-1, flt-1, and flt-4. bfh772 also targeted b-raf, ret, and tie-2, albeit with at least 40-fold lower potency. bfh772 inhibited the ligand induced autophosphorylation of ret, pdgfr, and kit kinases. bfh772 was selective against the kinases of egfr, erbb2, ins-r, and igf-1r and against the cytoplasmic bcr-abl kinase [1].
in vivothe dose response curves of bfh772 at 0.3, 1, and 3 mg/kg showed that even at the lowest concentrations, this naphthalene-1-carboxamide inhibited vegf induced tissue weight and tie-2 levels but only reached statistical significance at 1 mg/kg and above. moreover, bfh772 at 3 mg/kg orally dosed once per day could potently inhibit melanoma growth (54-90% for primary tumor and 71-96% for metastasis tumor) when compared with control ratios [1].
IC 503 nm
references[1] bold g, et al. a novel potent oral series of vegfr2 inhibitors abrogate tumor growth by inhibiting angiogenesis. j med chem. 2016 jan 14;59(1):132-46.
[2] http://adisinsight. springer.com/trials/700244037
BFH772 Preparation Products And Raw materials
Tag:BFH772(890128-81-1) Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.