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6-HYDROXYDOPAMINE HYDROCHLORIDE

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Products Intro: Product Name:6-HYDROXYDOPAMINE HYDROCHLORIDE
CAS:28094-15-7
Purity:98% Package:1g,10g,25g,100g,500g,1kg
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6-HYDROXYDOPAMINE HYDROCHLORIDE manufacturers

6-HYDROXYDOPAMINE HYDROCHLORIDE Basic information
Product Name:6-HYDROXYDOPAMINE HYDROCHLORIDE
Synonyms:4-(2-Aminoethyl)-1,2,3-benzenetriol hydrochloride;6-Hd HCl;Nsc233898;OxidopaMine Hydrochloride;2,4,5-TrihydroxyphenethylamineHCl;2,4,5-Trihydroxyphenethylaminehydochloride;2,4,5-TRIHYDROXYPHENETHYLAMINEYDOCHLORIDE;2,4,5-Trihydroxyphenethylamine hydrochloride, 2,5-Dihydroxytyramine hydrochloride, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride, 6-OHDA
CAS:28094-15-7
MF:C8H12ClNO3
MW:205.64
EINECS:248-837-2
Product Categories:
Mol File:28094-15-7.mol
6-HYDROXYDOPAMINE HYDROCHLORIDE Structure
6-HYDROXYDOPAMINE HYDROCHLORIDE Chemical Properties
Melting point 232-233 °C (dec.)(lit.)
storage temp. room temp
solubility H2O: >50 mg/mL, clear, yellow to brown
form powder
color off-white to brown
BRN 4274007
InChIInChI=1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChIKeyQLMRJHFAGVFUAC-UHFFFAOYSA-N
SMILESC1(CCN)=CC(=C(O)C=C1O)O.Cl
EPA Substance Registry System6-Hydroxydopamine hydrochloride (28094-15-7)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS DC4650000
3-8-10-23
MSDS Information
ProviderLanguage
SigmaAldrich English
6-HYDROXYDOPAMINE HYDROCHLORIDE Usage And Synthesis
Description6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death. 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.
Uses6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.
Uses6-hydroxydopamine hydrochloride has been used:
  • to induce Parkinson′s disease (PD) in rats
  • to analyse cytotoxic effect of 6-OHDA on PC12 cell line
  • to induce noradrenergic (NA) neuron deletion from the locus-coeruleus

General DescriptionBeige solid.
Air & Water ReactionsHygroscopic. Water soluble.
Reactivity ProfileA weak acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Health HazardACUTE/CHRONIC HAZARDS: When heated to decomposition 6-HYDROXYDOPAMINE HYDROCHLORIDE emits very toxic fumes.
Fire HazardFlash point data for 6-HYDROXYDOPAMINE HYDROCHLORIDE are not available. 6-HYDROXYDOPAMINE HYDROCHLORIDE is probably combustible.
Biological ActivitySelective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.
Biochem/physiol ActionsNeurotoxin that destroys catecholaminergic terminals.
Mechanism of actionThe biochemical mechanism of toxicity of 6-Hydroxydopamine hydrochloride (6-OHDA) is as follows: 6-OHDA has two modes of action: it readily forms free radicals and it is a potent inhibitor of the mitochondrial respiratory chain complexes I and IV. The inhibition of respiratory enzymes by 6-OHDA is reversible and insensitive to free radical scavengers and iron chelators, except for desferrioxamine. Moreover, free radicals are not involved in the interaction between 6-OHDA and the respiratory chain, and the two mechanisms are biochemically independent, although they may act synergistically in vivo.
6-HYDROXYDOPAMINE HYDROCHLORIDE Preparation Products And Raw materials
Tag:6-HYDROXYDOPAMINE HYDROCHLORIDE(28094-15-7) Related Product Information
Dopamine hydrochloride Acetylcholine Ethylamine hydrochloride Tyramine hydrochloride DOPAMINE HYDROCHLORIDE 5-HYDROXYDOPAMINE HYDROCHLORIDE,5-HYDROXYDOPAMINE HYDROCHLORIDE 99% RARECHEM AN KB 1616 RARECHEM AN KB 0077 RARECHEM AN KD 0076 RARECHEM AN KD 0298 RARECHEM AN KD 0559 RARECHEM AN KD 1619 6-HYDROXYDOPAMINE HYDROCHLORIDE