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| | DSR 6434 Basic information |
| Product Name: | DSR 6434 | | Synonyms: | DSR 6434;6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one;8H-Purin-8-one, 6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-;6-Amino-2-(butylamino)-9-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)methyl)-7,9-dihydro-8H-purin-8-one;DSR6434,DSR 6434;6-amino-2-(butylamino)-9-({6-[2-(dimethylamino)ethoxy]pyridin-3-yl}methyl)-8,9-dihydro-7H-purin-8-one | | CAS: | 1059070-10-8 | | MF: | C19H28N8O2 | | MW: | 400.48 | | EINECS: | | | Product Categories: | | | Mol File: | 1059070-10-8.mol |  |
| | DSR 6434 Chemical Properties |
| density | 1.283±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:145.03(Max Conc. mg/mL);362.12(Max Conc. mM) | | form | A solid | | pka | 10.22±0.20(Predicted) | | color | Light yellow to yellow |
| | DSR 6434 Usage And Synthesis |
| Uses | DSR 6434 (cas# 1059070-10-8) is a useful research chemical.DSR is a TLR7 agonist. DSR 6434 indicated an optimal balance between the agonistic potency and high water solubility. | | Biological Activity | DSR 6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist with EC50 of 7.2 nM and 4.6 nM for human and mouse TLR7, respectively. It has strong antitumor effect. | | in vitro | To assess the specificity of DSR-6434 toward TLR7, an NF-κB-driven reporter assay is performed in HEK293 cells engineered to express either hTLR7, TLR8 or TLR9. In this assay, successful binding of DSR-6434 to the specific receptor leads to NF-κB activation. | | target | | TLR7 7.2 nM (EC 50 , Human) | TLR7 4.6 nM (EC 50 , Mice) | | | storage | Store at -20°C |
| | DSR 6434 Preparation Products And Raw materials |
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