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BTSA 1

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:BTSA1
CAS:314761-14-3
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:BTSA1
CAS:314761-14-3
Purity:99.15% Package:2mg;38USD|5mg;64USD|10mg;122USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:BTSA1
CAS:314761-14-3
Purity:99% Package:5KG;1KG Remarks:BTSA1
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:BTSA1
CAS:314761-14-3
Purity:98% Package:5mg Remarks:V3168
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:BTSA1
CAS:314761-14-3
Package:10 mg；100 mg；2 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

BTSA 1 manufacturers

  • BTSA1
  • BTSA1 pictures
  • $38.00 / 2mg
  • 2024-11-17
  • CAS:314761-14-3
  • Min. Order:
  • Purity: 99.15%
  • Supply Ability: 10g
BTSA 1 Basic information
Product Name:BTSA 1
Synonyms:BTSA1 >=98% (HPLC);1H-Pyrazole-4,5-dione, 3-phenyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(2-thiazolyl)hydrazone];CS-2853;5-Phenyl-2-(4-phenyl-thiazol-2-yl)-4-(thiazol-2-yl-hydrazono)-2,4-dihydro-pyrazol-3-one;BTSA 1;BTSA-1;BTSA 1;inhibit,FITC-BIM,caspase-3/7,translocation,Bcl-2 Family,viability,Inhibitor,BTSA1,mitochondrial,pharmacologically,BAX,AML,BTSA 1,BTSA-1,SAHBA2,Apoptosis;5-Phenyl-2-(4-phenylthiazol-2-yl)-4-(2-(thiazol-2-yl)hydrazono)-2,4-dihydro-3H-pyrazol-3-one
CAS:314761-14-3
MF:C21H14N6OS2
MW:430.51
EINECS:
Product Categories:API
Mol File:314761-14-3.mol
BTSA 1 Structure
BTSA 1 Chemical Properties
Boiling point 625.2±48.0 °C(Predicted)
density 1.49±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO:53.0(Max Conc. mg/mL);123.11(Max Conc. mM)
pka6.52±0.40(Predicted)
form Solid
color Brown to reddish brown
Safety Information
MSDS Information
BTSA 1 Usage And Synthesis
UsesBTSA1 is a potent, high affinity and orally active BAX activator with an IC50 of 250 nM and an EC50 of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis[1].
Biological ActivityBTSA1 is a BAX activator that binds to its N-terminal activation site with high affinity and specificity, induces a conformational change in BAX, and causes BAC-mediated apoptosis. It efficiently promotes apoptosis in leukemia cell lines and patient samples without affecting healthy cells.
in vivoBTSA1 effectively inhibits human acute myeloid leukemia xenografts and enhances host survival without toxic side effects. In mice, it was well tolerated.
target
TargetValue
Bax
()
IC 50Bax: 250 nM (IC50); Bax: 144 nM (EC50)
References[1] Reyna DE, et al. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 2017 Oct 9;32(4):490-505.e10. DOI:10.1016/j.ccell.2017.09.001
BTSA 1 Preparation Products And Raw materials
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