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K-756

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K-756 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:K-756
CAS:130017-40-2
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:K-756
CAS:130017-40-2
Purity:98.00% Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:K-756
CAS:130017-40-2
Purity:99% Package:$130.9/5mg;$210.9/10mg;$720.9/50mg;$1150.9/100mg;Bulk package Remarks:99%
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ:65489617 15618227136
Email: info@SuperLan-chem.com
Products Intro: Product Name:K-756
CAS:130017-40-2
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
Company Name: Angel Pharmatech, Ltd.  
Tel: 17317130613
Email: 3358272972@qq.com
Products Intro: Product Name:K-756
CAS:130017-40-2
Purity:98% HPLC Package:1G;5G
K-756 Basic information
Product Name:K-756
Synonyms:K-756;2(1H)-Quinazolinone, 3-[[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]methyl]-3,4-dihydro-;K-756 >=98% (HPLC);K-756,PARP,Inhibitor,poly ADP ribose polymerase,K756,K 756,inhibit
CAS:130017-40-2
MF:C24H27N5O3
MW:433.5
EINECS:
Product Categories:
Mol File:130017-40-2.mol
K-756 Structure
K-756 Chemical Properties
Melting point 216-218 °C
Boiling point 680.0±55.0 °C(Predicted)
density 1.261±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:4.55(Max Conc. mg/mL);10.5(Max Conc. mM)
pka14.92±0.20(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
K-756 Usage And Synthesis
DescriptionK-756 is a a selective Wnt/β-catenin pathway inhibitor. K-756 is also a tankyrase (TNKS) inhibitor. K-756 binds to the induced pocket of TNKS and inhibits its enzyme activity. could be a leading compound in the development of anticancer agents.
in vitroK-756 binds to the induced pocket of TNKS and inhibits its enzyme activity. Moreover, PARP family enzyme assays showed that K-756 is a selective TNKS inhibitor. K-756 inhibited the cell growth of APC-mutant colorectal cancer COLO 320DM and SW403 cells by inhibiting the Wnt/β-catenin pathway. _x000D_ _x000D_ Reference: Mol Cancer Ther. 2016 Jul;15(7):1525-34. https://pubmed.ncbi.nlm.nih.gov/27196752/
in vivoAn in vivo study showed that the oral administration of K-756 inhibited the Wnt/β-catenin pathway in colon cancer xenografts in mice._x000D_ _x000D_ Reference: Mol Cancer Ther. 2016 Jul;15(7):1525-34. https://pubmed.ncbi.nlm.nih.gov/27196752/
targetK-756 is a direct and selective tankyrase (TNKS) inhibitor, which inhibits the ADP-ribosylation activity of TMS1 amd TMLS2 with IC50s of 31 and 36 nM, respectively.
K-756 Preparation Products And Raw materials
Raw materials3-(piperidin-4-ylmethyl)-3,4-dihydroquinazolin-2(1H)-one-->4-Chloro-6,7-dimethoxyquinazoline
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