- (BOC-AMINOOXY)ACETIC ACID
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- $15.00 / 1KG
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2021-08-12
- CAS:42989-85-5
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | (Boc-aminooxy)acetic Acid Basic information |
| | (Boc-aminooxy)acetic Acid Chemical Properties |
| Melting point | ~115 °C (dec.) | | density | 1.214±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Soluble in methanol. | | form | Solid | | pka | 2.97±0.10(Predicted) | | color | White to Off-White | | BRN | 6137646 | | InChI | InChI=1S/C7H13NO5/c1-7(2,3)13-6(11)8-12-4-5(9)10/h4H2,1-3H3,(H,8,11)(H,9,10) | | InChIKey | QBXODCKYUZNZCY-UHFFFAOYSA-N | | SMILES | C(O)(=O)CONC(OC(C)(C)C)=O | | CAS DataBase Reference | 42989-85-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 2928 00 90 | | HazardClass | IRRITANT |
| | (Boc-aminooxy)acetic Acid Usage And Synthesis |
| Chemical Properties | White powder | | Uses | (Boc-aminooxy)acetic acid was used in the preparation of Boc-aminooxy tetra(ethylene glycol). | | Uses | A Boc-protected bifunctional linking reagent | | Uses | (Boc-aminooxy)acetic acid was employed to introduce a hydroxylamine moiety into peptides; reaction with an aldehyde to an oxime. It was used in the preparation of Boc-aminooxy tetra(ethylene glycol). | | Synthesis | (Boc-aminooxy)acetic acid is prepared by the reaction of Di-tert-butyl dicarbonate and Aminooxyacetic acid. The specific synthesis steps are as follows:
A 500 mL round-bottom flask was charged with a suspension of aminooxyacetic acid (4 g, 36.6 mmol) in CH2Cl2 (100 mL).
The solution was cooled to 0° C. and triethylamine (16 mL, 114 mmol) was added dropwise while stiffing to dissolve all solids.
To this mixture was added a solution of di-tert-butyl dicarbonate (12 g, 55 mmol) in CH2Cl2 (20 mL).
The reaction was stirred for 30 min at 0° C., then continued for 1 h at rt.
The solution was washed with three 100 mL portions of water.
The aqueous portion was combined and extracted with two 100 mL portions of EtOAc; this EtOAc was discarded.
The pH of the aqueous portion was adjusted to 3.5 with 1 M HCl, then extracted with five 50 mL portions of EtOAc, adjusting to maintain pH 3.5 as needed.
The combined EtOAc was dried over Na2SO4, filtered, and the solvent removed in vacuo to afford a white crystalline powder (5.8 g, 83percent). TLC: (MeOH:CH2Cl2, 1:9) Rf=0.08. 1H NMR (400 MHz, CD3OD): δ 1.48 (s, 9H), 4.47 (s, 2H), 7.94 (s, 1H).
13C NMR (100 MHz, CD OD): δ, 27.1, 47.0, 72.3, 81.4, 157.8, 171.3.
 | | Solubility in organics | Soluble in DCM, THF, DMF and DMSO |
| | (Boc-aminooxy)acetic Acid Preparation Products And Raw materials |
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