| Company Name: |
Chemsky（shanghai）International Co.,Ltd.
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:4-Benzyloxyphenylhydrazine
CAS:51145-58-5
Purity:98%+ Package:1500RMB/1G; 3000RMB/5G
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| Company Name: |
SynAsst Chemical.
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| Tel: |
021-60343070 |
| Email: |
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| Products Intro: |
Product Name:(4-Benzyloxy-phenyl)-hydrazine
CAS:51145-58-5
Purity:96%Min Package:10g 100g 500g
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| | 4-Benzyloxyphenylhydrazine Basic information |
| | 4-Benzyloxyphenylhydrazine Chemical Properties |
| | 4-Benzyloxyphenylhydrazine Usage And Synthesis |
| Uses | (4-Phenylmethoxyphenyl)hydrazine is used as a reactant in the preparation of indolyl thiazole derivatives as xanthine oxidase inhibitors and antiinflammatory drugs. | | Manufacturing Process | Preparation of 4-benzyloxyphenylhydrazine: 200 grams 4-benzyloxyaniline hydrochloride was suspended in a mixture of 264 ml concentrated hydrochloric acid, 528 ml water and 732 grams crushed ice. A solution of 62.4 grams sodium nitrite in 136 ml water was added below the surface of the stirred suspension at -10-(+/-)2°C during 10 minutes. After stirring for 1 hour at 0°C, the suspension was treated with acid-washed charcoal and filtered.
The filtrate was cooled and maintained at -8°C while a solution of 500 grams of stannous chloride in 760 ml concentrated hydrochloric acid was added with stirring. The mixture was stirred for 2 hours at -8°C and the 4- benzyloxyphenylhydrazine hydrochloride which separated was filtered off and washed with water. The product was crystallized by adding 800 ml hot water to a 3 liter solution in ethanol and had a MP of 185° to 189°C (yield 168.5 grams, 79%). |
| | 4-Benzyloxyphenylhydrazine Preparation Products And Raw materials |
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