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| 1,3,5-Trimethoxybenzene Basic information |
Product Name: | 1,3,5-Trimethoxybenzene | Synonyms: | TRISMETHOXYBENZENE;1,3,5-TriMethoxybenzene ReagentPlus(R), >=99%;1,3,5-TriMetho;1,3,5-trimethoxy-benzen;3,5-DIMETHOXYANISOLE;1,3,5-TRIMETHOXYBENZENE;1,3,5-Trimethoxybenzene/Phloroglucinol trimethyl ether;O,O,O-1,3,5-trimethylresorcinol | CAS: | 621-23-8 | MF: | C9H12O3 | MW: | 168.19 | EINECS: | 210-673-4 | Product Categories: | Benzene derivates;Aromatic Ethers;ACTIVE PHARMACEUTICAL INGREDIENTS;621-23-8;API | Mol File: | 621-23-8.mol | |
| 1,3,5-Trimethoxybenzene Chemical Properties |
Melting point | 50-53 °C (lit.) | Boiling point | 255 °C (lit.) | density | 1,126g/cm | refractive index | 1,533 | Fp | 186 °F | storage temp. | Sealed in dry,Room Temperature | solubility | methanol: 0.1 g/mL, clear, colorless | form | Crystalline Powder | color | White to cream | Water Solubility | insoluble | BRN | 1307993 | InChIKey | LKUDPHPHKOZXCD-UHFFFAOYSA-N | LogP | 1.605 (est) | CAS DataBase Reference | 621-23-8(CAS DataBase Reference) | NIST Chemistry Reference | 1,3,5-Trimethoxybenzene(621-23-8) | EPA Substance Registry System | 1,3,5-Trimethoxybenzene (621-23-8) |
Hazard Codes | Xn,F | Risk Statements | 22-20/21/22 | Safety Statements | 24/25-36-26 | RIDADR | 1325 | WGK Germany | 3 | RTECS | DC2810000 | Hazard Note | Flammable Solid/Harmful | TSCA | Yes | HazardClass | 4.1 | PackingGroup | III | HS Code | 29093090 |
| 1,3,5-Trimethoxybenzene Usage And Synthesis |
Chemical Properties | white to cream crystalline powder. Insoluble in water. | Uses | 1,3,5-Trimethoxybenzene is a major scent component of the Chinese rose odour. 1,3,5-Trimethoxybenzene is also a useful synthetic intermediate and is used to synthesize triaryl- and triheteroarylmethanes. | Definition | ChEBI: 1,3,5-trimethoxybenzene is a methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. It has a role as a biomarker and a human xenobiotic metabolite. | General Description | 1,3,5-Trimethoxybenzene effectively cleaves p-methoxybenzyl protecting group on various alcohols and acids. It is the major scent compound present in Chinese rose species. | Synthesis | A solution of anhydrous phloroglucinol (6.3 g,0.05 mole) in dryacetone (100 ml) is refluxed for 6 hr under anhydrous conditions withdimethyl sulphate (15. 6 ml,20.8 g, 0.165 mole) in presence of ignitedpotassium carbonate (40 g).The mixture is filtered, and the inorganic saltswashed with hot acetone (2 × 20 ml). The combined acetone solution isdistilled and the residue macerated with crushed ice. It is extracted withether, the ether extracts washed with sodium hydroxide solution (5%),water,dried (sodium sulphate) and distilled. Yield 1,3,5-Trimethoxybenzene 6 g (71.4 %).M.p 52-3° (lit. m.p.52-53°).
| Solubility in organics | Soluble in Methanol, Ether, Ethanol, Benzene. | Solubility in water | Insoluble | Purification Methods | Sublime it under vacuum. [Beilstein 6 III 635, 6 IV 7362.] |
| 1,3,5-Trimethoxybenzene Preparation Products And Raw materials |
Raw materials | 3,5-Dibromoanisole-->1-Bromo-3,5-dimethoxybenzene-->Sodium Methoxide-->1,3,5-Tribromobenzene | Preparation Products | P276-->dracorhodin-->2',4',6'-TRIMETHOXYACETOPHENONE-->1,2,3,6-TETRAHYDRO-1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-PYRIDINE |
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