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| | 4-(Bromomethyl)tetrahydropyran Basic information |
| | 4-(Bromomethyl)tetrahydropyran Chemical Properties |
| Boiling point | 88 °C | | density | 1.359±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | form | liquid | | color | Light beige/brown | | InChI | InChI=1S/C6H11BrO/c7-5-6-1-3-8-4-2-6/h6H,1-5H2 | | InChIKey | LMOOYAKLEOGKJR-UHFFFAOYSA-N | | SMILES | C1OCCC(CBr)C1 | | CAS DataBase Reference | 125552-89-8(CAS DataBase Reference) |
| | 4-(Bromomethyl)tetrahydropyran Usage And Synthesis |
| Chemical Properties | Viscous liquid | | Uses | 4-(Bromomethyl)tetrahydropyran is an important organic synthesis intermediate, widely used in the fields of medicine, pesticides and dyes. It can be used to synthesize a variety of biologically active compounds, such as antibacterial agents, anti-tumor drugs, nervous system drugs and fluorescent dyes. In addition, 4-(Bromomethyl)tetrahydropyran can also be used to synthesize organic pigments and functional materials. | | Synthesis | To a solution of Tetrahydropyran-4-methanol and N-bromobutanimide (NBS) in DCM was added PPh3 at 0°C. The reaction mixture was stirred at room temperature for 1–2h. The resulting mixture was washed with water (20mL) and brine (3×20mL). The organic layer was concentrated and the residue was purified by silica gel flash chromatography (eluting with ethyl acetate in petroleum ether 2–5%) to give 4-(Bromomethyl)tetrahydropyran as a colorless oil.
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| | 4-(Bromomethyl)tetrahydropyran Preparation Products And Raw materials |
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