N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
| 中文名称 | N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺 |
|---|---|
| 中文同义词 | N-(4-碘苯基)-5-硝基-2-呋喃甲酰胺;化合物C-176;N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺;C-176, STING 抑制剂 |
| 英文名称 | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide |
| 英文同义词 | N-(4-iodophenyl)-5-nitrofuran-2-carboxamide;C-176;C-176 STING inhibitor;STING inhibitor 1;2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-;N-(4-iodophenyl)-5-nitro-2-furamide;STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA |
| CAS号 | 314054-00-7 |
| 分子式 | C11H7IN2O4 |
| 分子量 | 358.09 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 314054-00-7.mol |
| 结构式 |  |
N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺 性质
| 沸点 | 361.2±37.0 °C(Predicted) |
|---|---|
| 密度 | 1.935±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C(protect from light) |
| 溶解度 | 溶于DMSO（高达25mg/ml） |
| 酸度系数(pKa) | 11.14±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 棕色或黄色 |
| 稳定性 | 可在-20°C的DMSO中的溶液下储存长达3个月。 |
STING inhibitor C-176是一种有效的STING抑制剂。STING是细胞内DNA感应通路的主要信号分子。
| Target | Value |
|
STING
() |
C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.
C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.
C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1
−/−
mice.
C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1
−/−
mice.
| Animal Model: | WT type mice. |
| Dosage: | 750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL). |
| Administration: | Intraperitoneally, once. |
| Result: | Significantly reduced Serum levels of type I IFNs and IL-6. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | S6575 | N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺 C-176 (STING inhibitor) | 314054-00-7 | 5mg | 877.13元 |
| 2024/04/30 | S6575 | N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺 C-176 (STING inhibitor) | 314054-00-7 | 10mM(1mL in DMSO) | 997元 |