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VU 0409106

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Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:VU0409106；VU 0409106;VU-0409106
CAS:1276617-62-9
Package:10 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
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Products Intro: Product Name:VU 0409106
CAS:1276617-62-9
Purity:>=98%(HPLC) Package:$155.9/10mg;$655.9/50mg;Bulk package Remarks:98%(HPLC)
Company Name: TargetMol Chemicals Inc.
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Email: zijue.cai@tsbiochem.com
Products Intro: Product Name:VU0409106
CAS:1276617-62-9
Package:100mg;2500USD|50mg;1980USD|25mg;1520USD
Company Name: Shanghaizehan biopharma technology co., Ltd.  
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Products Intro: Product Name:VU0409106
CAS:1276617-62-9
Purity:98% Package:1g;5g
Company Name: Shanghai Rechem science Co., Ltd.  
Tel: 21-31433387 15618786686
Email: sales@rechemscience.com
Products Intro: CAS:1276617-62-9
Purity:98% Package:1g;5g

VU 0409106 manufacturers

  • VU0409106
  • VU0409106 pictures
  • $2500.00 / 100mg
  • 2024-10-24
  • CAS:1276617-62-9
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  • Supply Ability: 10g
VU 0409106 Basic information
Product Name:VU 0409106
Synonyms:VU 0409106;3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide;Benzamide, 3-fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)-
CAS:1276617-62-9
MF:C15H11FN4O2S
MW:330.34
EINECS:
Product Categories:
Mol File:1276617-62-9.mol
VU 0409106 Structure
VU 0409106 Chemical Properties
density 1.445±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka6.61±0.50(Predicted)
color White to off-white
Safety Information
MSDS Information
VU 0409106 Usage And Synthesis
UsesVU 0409106 is a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5). VU0409106 also was effective in a mouse marble burying anxiety behaviour.
in vivo

VU0409106 (10 mg/kg; i.p.; once) penetrates the blood-brain barrier (BBB) and demonstrates good brain to plasma ratio that near unity[1].

Animal Model:CD-1 mice[1]
Dosage:10 mg/kg (10% Tween 80 formulation)
Administration:Intraperitoneal injection.
Result:1.19Pharmacokinetic Parameters of VU0409106 in CD-1 mice[1].
IP (10 mg/kg)
Plasma Tmax (h)0.25
Plasma Cmax (ng/mL)1450
Brain Tmax (h)0.25
Brain Cmax (ng/mL)1350
AUCplasma (ng/mL?h)702
AUCbrain (ng/mL?h)696
B/P ratio0.99
IC 50mGlu5: 24 nM (IC50)
VU 0409106 Preparation Products And Raw materials
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