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| Product Name: | CA-5f | | Synonyms: | CA-5f;CA-5F;CA 5F;CA5F;1370032-19-1;4-Piperidinone, 3-[(3,4-dimethoxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-;-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-;(E)-3-((1H-Indol-3-yl)methylene)-5-((E)-3,4-dimethoxybenzylidene)-1-methylpiperidin-4-one;CA-5f,Apoptosis,inhibit,Autophagy,Inhibitor,CA 5f,CA5f;(3E,5E)-3-(3,4-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one | | CAS: | 1370032-19-1 | | MF: | C24H24N2O3 | | MW: | 388.46 | | EINECS: | | | Product Categories: | API | | Mol File: | 1370032-19-1.mol |  |
| | CA-5f Chemical Properties |
| Boiling point | 639.7±55.0 °C(Predicted) | | density | 1.253±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 77.5 mg/mL (199.51 mM);Water : < 0.1 mg/mL (insoluble) | | pka | 16.06±0.30(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | CA-5f Usage And Synthesis |
| Biological Activity | CA-5f is a potent late macroautophagy/autophagy inhibitor, acting by inhibiting autophagosome-lysosome fusion. It increases LC3B-II (a marker that monitors autophagy) and SQSTM1 protein levels and promotes ROS production. Has antitumor activity. | | in vivo | CA-5f (40 mg/kg, ip, every 2 days for up to 30 days) is well tolerated, and potently inhibits the growth of tumor in nude mice bearing A549 lung cancer cells.
CA-5f (40 mg/kg, ip) suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells.
| Animal Model: | < td class="col2"> Nude mice bearing A549 lung cancer cells | Dosage: | 40 mg /kg | | Administration: | Injected via caudal vein, every 2 days for up to 30 days < /td> | | Result: | Significantly suppressed tumor volume and weight in mice, increased the number of apoptotic cells in mice . | | | target | |
| | CA-5f Preparation Products And Raw materials |
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