| Company Name: |
Amadis Chemical Company Limited |
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571-89925085 |
| Email: |
sales@amadischem.com |
| Products Intro: |
Product Name:1H-Pyrazino[3,2,1-jk]carbazole,2,3,3a,4,5,6-hexahydro-8-methyl-
CAS:60762-57-4
Purity:0.97 Package:mgs,gs,kgs Remarks:A899813
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino-[3,2,1-jk]carbazole methanesulfonate
CAS:60762-57-4
Package:500mg
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| | 2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE Basic information |
| Product Name: | 2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE | | Synonyms: | PIRLINDOLE MESYLATE;2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino[3,2,1-jk]carbazole;8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole;16154-78-2 (Hydrochloride);Pirlindol;Pirlindol [inn-spanish, french];Pirlindolum;Pirlindolum [inn-latin] | | CAS: | 60762-57-4 | | MF: | C15H18N2 | | MW: | 226.32 | | EINECS: | | | Product Categories: | Monoamine Oxidase | | Mol File: | 60762-57-4.mol | ![2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE Structure](CAS/GIF/60762-57-4.gif) |
| | 2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE Chemical Properties |
| storage temp. | Store at RT | | solubility | DMF: 1 mg/ml; DMSO: 5 mg/ml | | form | A crystalline solid | | color | Off-white to light yellow |
| | 2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE Usage And Synthesis |
| Description | Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively). It is selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC50 value of 7.7 μM independent of MAO-A activity. | | Uses | Antidepressive;Monoamine oxidase inhibitor | | Biological Activity | A highly selective reversible inhibitor of monoamine oxidase type A. |
| | 2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE Preparation Products And Raw materials |
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