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N-ACETYL-4-BENZOQUINONE IMINE

N-ACETYL-4-BENZOQUINONE IMINE Suppliers list
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Products Intro: Product Name:Phenylephrine Impurity 23(N-Acetyl-4-Benzoquinone Imine)
CAS:50700-49-7
Purity:0.99 Package:10mg;25mg;50mg;100mg
Company Name: Shaanxi Dideu Medichem Co. Ltd
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Products Intro: Product Name:N-Acetylbenzoquinoneimine
CAS:50700-49-7
Purity:99.0% Package:100g;1kg;5kg;25kg
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Products Intro: Product Name:N-Acetylbenzoquinoneimine
CAS:50700-49-7
Package:1g; 5g; 25g; 1kg; 5kg; 25kg
Company Name: China National Standard Pharmaceutical Corporation Limited
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Products Intro: Product Name:Phenylephrine Impurity 23(N-Acetyl-4-Benzoquinone Imine)
CAS:50700-49-7
Purity:0.95 Package:Vials
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Email: market18@leapchem.com
Products Intro: Product Name:N-Acetylbenzoquinoneimine
CAS:50700-49-7
Package:1g; 5g; 25g; 1kg; 5kg; 25kg
N-ACETYL-4-BENZOQUINONE IMINE Basic information
Product Name:N-ACETYL-4-BENZOQUINONE IMINE
Synonyms:N-ACETYLBENZOQUINONE-IMINE;N-N-Acetyl-4-benzoquinone Imine;N-ACETYL-PARA-QUINONEIMINE;N-Acetyl-p-benzoquinone imine (NAPQI), 98%;4-(Acetylimino)-2,5-cyclohexadien-1-one;N-(4-Oxo-1-cyclohexa-2,5-dienylidene)acetamide, N-Acetyl-p-benzo-quinone imine, NAPQI;N-Acetyl-1,4-benzoquinone imine;Chebi:29132
CAS:50700-49-7
MF:C8H7NO2
MW:149.15
EINECS:
Product Categories:Chemical Synthesis;Imines/Amidines;Nitrogen Compounds;Organic Building Blocks;Building Blocks;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Elisa Kit-Mouse Elisa Kit
Mol File:50700-49-7.mol
N-ACETYL-4-BENZOQUINONE IMINE Structure
N-ACETYL-4-BENZOQUINONE IMINE Chemical Properties
Melting point 74-75
Boiling point 255.6±43.0 °C(Predicted)
density 1.13±0.1 g/cm3(Predicted)
storage temp. -70°C
solubility Chloroform (Slightly, Sonicated), DMSO (Slightly)
form Solid
pka-3.37±0.20(Predicted)
color Pale Yellow to Very Dark Red
Stability:Temperature, Moisture, Light, and Oxygen Sensitive
CAS DataBase Reference50700-49-7
Safety Information
WGK Germany 3
RTECS AC6960000
HS Code 2902110000
ToxicityLD50 i.p. in male BALB/c mice: 20 mg/kg (Dahlin, Nelson)
MSDS Information
ProviderLanguage
SigmaAldrich English
N-ACETYL-4-BENZOQUINONE IMINE Usage And Synthesis
DescriptionN-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.
Chemical PropertiesYellow Crystalline Solid
UsesReactant involved in:• ;Redox reactions1• ;Hydrohalogenation2• ;pH dependent reactions: in acidic media it is hydrolyzed, hydroxylated in alkaline media, and dimerized at intermediate pHs3• ;Mediation of acetaminophen hepatotoxicity4• ;Studies to identify the utility of acetaminophen for treating autoimmune disorders5
UsesA toxic metabolite of Acetaminophen (A161220), which reacts with serum proteins.
UsesA toxic metabolite of Acetaminophen, which reacts with serum proteins
UsesN-Acetyl-4-benzoquinone imine (NAPQI) is a cytochrome P450 3A4 and 2E1 metabolite of acetaminophen that can be toxic to the liver when acetaminophen is consumed in large doses. At therapeutic doses of acetaminophen, NAPQI is inactivated by conjugation with glutathione. However, following toxic doses of acetaminophen, available liver reserves of glutathione are quickly depleted due to clearance of excess NAPQI, which enables hepatic proteins to become covalently modified by reactive metabolites and eventually results in hepatocyte necrosis.
DefinitionChEBI: N-acetyl-1,4-benzoquinone imine is a quinone imine and a ketoimine. It is functionally related to a 1,4-benzoquinone imine.
N-ACETYL-4-BENZOQUINONE IMINE Preparation Products And Raw materials
Preparation Products3-CHLORO-4-HYDROXYACETANILIDE-->Acetaminophen
Tag:N-ACETYL-4-BENZOQUINONE IMINE(50700-49-7) Related Product Information
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