Y-27632二盐酸盐
| 中文名称 | Y-27632二盐酸盐 |
|---|---|
| 中文同义词 | 4-[(1R)-1-氨基乙基]-N-(吡啶-4-基)环己烷-1-甲酰胺二盐酸盐;Y-27632二盐酸盐;4-[(1R)-1-氨基乙基]-N-(吡啶-4-基)环己烷-1-甲酰胺;ROCK抑制剂(AZAINDOLE1);ROCK-I和ROCK-II抑制剂(Y-27632);反式-4-(R-1-氨基乙基)-N-(吡啶-4-基)环己烷甲酰胺;ROCK-I和ROCK-II抑制剂;TRANS-4-((R)-1-氨基乙基)-N-(吡啶-4-基)环己烷甲酰胺 |
| 英文名称 | Y-27632 DIHYDROCHLORIDE |
| 英文同义词 | (R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL)-CYCLOHEXANECARBOXAMIDE 2HCL;(R)-(+)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL)CYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE;(+)-R-TRANS-4-(AMINOETHYL)-N-(4-PYRIDYL)-CYCLOHEXANECARBOXAMIDE 2HCL H2O;Y-27632 DIHYDROCHLORIDE;TRANS-4-[(1R)-1-AMINOETHYL]-N-4-PYRIDINYLCYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE;4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide dihydrochloride;(1R,4r)-4-((R)-1-aMinoethyl)-N-(pyridin-4-yl)cyclohexanecarboxaMide dihydrochloride;CyclohexanecarboxaMide,4-[(1R)-1-aMinoethyl]-N-4-pyridinyl-, trans- |
| CAS号 | 146986-50-7 |
| 分子式 | C14H21N3O |
| 分子量 | 247.34 |
| EINECS号 | 1312995-182-4 |
| 相关类别 | 高纯试剂;医药中间体;小分子抑制剂;小分子抑制剂，天然产物;细胞生物学试剂;Protein Kinase;Signalling;Inhibitor;Inhibitors;APIs;激素;医药原料;医用原料 |
| Mol文件 | 146986-50-7.mol |
| 结构式 |  |
Y-27632二盐酸盐 性质
| 熔点 | >260°C (dec.) |
|---|---|
| 沸点 | 462.6±15.0 °C(Predicted) |
| 密度 | 1.136±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Sealed in dry,2-8°C |
| 溶解度 | H2O: 14 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 13.53±0.40(Predicted) |
| 颜色 | 白色 |
| 稳定性 | 吸湿性 |
|
ROCK-I 220 nM (Ki) |
ROCK-II 300 nM (Ki) |
PKN 3.1 μM (Ki) |
Citron kinase 5.3 μM (Ki) |
PKCα 73 μM (Ki) |
PKA 25 μM (Ki) |
Y-27632 inhibits the ROCK family of kinases 100 times more potently than other kinases including protein kinase C, cAMP-dependent kinase and myosin light chain kinase. Y-27632 prolongs the lag time and delays the appearance of BrdU-labeled cells in a concentration-dependent manner, delays of about 1 and 4 h are noticed in the Swiss 3T3 cells treated with 10 and 100 μM Y-27632, respectively. Y-27632 promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs). Compared to 1.0 and 2.5 μM Y-27632 induced groups, percentages of neuroal-like cells achieved a peak in the 5.0 μM Y-27632 induced group.
Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group. Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group).
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英文
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