- Exo1
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- $38.00 / 10mg
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2024-11-19
- CAS:75541-83-2
- Min. Order:
- Purity: 99.56%
- Supply Ability: 10g
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| Product Name: | EXO1 | | Synonyms: | 4-FLUORO-BZ-2-ABZ-OME;2-(4-FLUOROBENZOYLAMINO)BENZOIC ACID METHYL ESTER;2-(4-FLUOROBENZOYLAMINO)METHYLBENZOATE;2-(4-Fluoro-benzoylami;2-(4-Fluorobenzoylamino)benzoic acid methyl ester, 2-(4-Fluorobenzoylamino)methylbenzoate;EOX 1;EXOCYTIC INHIBITOR 1;EXO1 | | CAS: | 75541-83-2 | | MF: | C15H12FNO3 | | MW: | 273.26 | | EINECS: | | | Product Categories: | | | Mol File: | 75541-83-2.mol |  |
| storage temp. | +2C to +8C | | solubility | DMSO: 19 mg/mL, soluble | | form | solid | | color | White to off-white |
| Uses | Exo 1 acts as a cell-permeable reverse inhibitor of exocytosis. Potential anti-inflammatory activity. | | Uses | Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the long?interspersed?nuclear?element-1 (L1) retrotransposition. | | Uses | Exo1 is a cell-permeable, reversible inhibitor of exocytosis (IC50 = 20 μM). It interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by dissociating the GTPase activator ADP-ribosylation factor (ARF1) from Golgi membranes, which leads to a consequent collapse of the Golgi apparatus. | | Definition | ChEBI: 2-[[(4-fluorophenyl)-oxomethyl]amino]benzoic acid methyl ester is a member of benzamides. | | Biochem/physiol Actions | Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies. |
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