4-(9-ADENYL)-D-ERYTHRO-2,3-DIHYDROXYBUTYRIC ACID manufacturers
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| 4-(9-ADENYL)-D-ERYTHRO-2,3-DIHYDROXYBUTYRIC ACID Basic information |
| 4-(9-ADENYL)-D-ERYTHRO-2,3-DIHYDROXYBUTYRIC ACID Chemical Properties |
Melting point | >270°C (dec.) | Boiling point | 721℃ | alpha | D +51.4° (c = 1.6 in 0.1N NaOH) | density | 1.92 | refractive index | 1.7610 (estimate) | Fp | 390℃ | storage temp. | Refrigerator | solubility | Aqueous Acid (Slightly, Heated), DMSO (Slightly) | form | Solid | pka | 3.37±0.17(Predicted) | color | White to Light Beige |
| 4-(9-ADENYL)-D-ERYTHRO-2,3-DIHYDROXYBUTYRIC ACID Usage And Synthesis |
Description | The empirical formula of this alkaloid should read C9H II N 504' The natural
compound is the D-Erythro-form of the base. Melting points recorded for this
alkaloid are 279°C (dec.) by Kamiya et al and 26l-3°C (dec.) by Chibata and
his colleagues. The alkaloid has specific rotations of [α]D+ 16° (N-HC1) and
[α] D + 50° (0.1 N-NaOH). It gives an ultraviolet spectrum in H20 with a single
absorption maximum at 26l.5 nm which is shifted to 259.5 nm inN-HCl and is
at 262 nm in N-NaOH. Eritadenine forms a methyl ester, m.p. 231°C (dec.) and
a diacetate, m.p. 225°C (dec.). | Chemical Properties | Pale Yellow Solid | Uses | Hypocholesterolemic isolated from shiitake mushrooms, effecting phospholipid and linoleic acid metabolisms. Specifically, Eritadenine is a potent inhibitor of S-adenosyl-L-homocysteine hydrolase (SAHH), decreasing total cholesterol levels in plasma. | References | Chibata et al., Experientia, 25,1237 (1969) Kamiya et al., Tetrahedron Lett., 4729 (1969) |
| 4-(9-ADENYL)-D-ERYTHRO-2,3-DIHYDROXYBUTYRIC ACID Preparation Products And Raw materials |
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