甲磺酸阿米三嗪
| 中文名称 | 甲磺酸阿米三嗪 |
|---|---|
| 中文同义词 | N,N'-二烯丙基-6-[4-[二(4-氟苯基)甲基]哌嗪-1-基]-1,3,5-三嗪-2,4-二胺二甲磺酸盐;甲磺酸阿米三嗪;二甲基阿咪三嗪;二甲磺酸阿米三嗪(标准品);N2,N4-二烯丙基-6-(4-(双(4-氟苯基)甲基)哌嗪-1-基)-1,3,5-三嗪-2,4-二胺二甲磺酸盐 |
| 英文名称 | Almitrine dimesylate |
| 英文同义词 | ALMITRINE BISMESYLATE;ALMITRINE DIMESYLATE;2,4-bis(allylamino)-6-[4-[bis(p-fluorophenyl)methyl]-1-piperazinyl]-s-triazine dimethanesulfonate;n,n'-diallyl-6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1,3,5-triazine-2,4-diamine dimethanesulphonate;ALMITRINE DIMESILATE;Mesylate AlMitrine;N2,N4-Diallyl-6-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-1,3,5-triazine-2,4-diamine dimethanesulfonate;Almitrine bismethanesulfonate |
| CAS号 | 29608-49-9 |
| 分子式 | C28H37F2N7O6S2 |
| 分子量 | 669.76 |
| EINECS号 | 249-726-1 |
| 相关类别 | 药物标准品;医药原料;医药中间体;标准品;中药对照品;原料药;化学试剂;医用原料 |
| Mol文件 | 29608-49-9.mol |
| 结构式 |  |
甲磺酸阿米三嗪 性质
| 熔点 | 243° (dec) |
|---|---|
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 可溶于氯仿（少许）、甲醇（少许） |
| 形态 | 固体 |
| 颜色 | 白色 |
K + channel
Almitrine inhibits the activity of a high-conductance (152±13 pS), Ca 2+ -dependent K + channel by decreasing its open probability. The IC 50 value of the effect is 0.22 μM. The inhibitory effect of Almitrine on Ca 2+ -dependent K + channels also is observed in GH3 cells. Almitrine at concentrations up to 10 μM does not affect whole-cell voltage-dependent K + , Ca 2+ , or Na + currents in rat or rabbit cells. However, this concentration of Almitrine significantly inhibits the Ca 2+ -dependent component of K + currents in rat chemoreceptor cells.
Almitrine acts via the peripheral arterial chemoreceptors raising carotid sinus nerve output and minute ventilation. Almitrine also has a pulmonary vascular action causing a dose-dependent constriction and dilatation. At low doses Almitrine enhances hypoxic pulmonary vasoconstriction and may improve the overall ventilation/perfusion ratio.
安全信息
| 毒性 | LD50 in mice: 210 mg/kg i.v., 390 mg/kg i.p., >2 g/kg orally (Regnier) |
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