| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:BIBU 1361 dihydrochloride;N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylaMino)Methyl]-1-piperidinyl]-pyriMido[5,4-d]pyriMidin-4-aMinedihydrochloride
CAS:793726-84-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:BIBU 1361 dihydrochloride
CAS:793726-84-8
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
BOC Sciences
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| Tel: |
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| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:BIBU 1361 dihydrochloride
CAS:793726-84-8
Purity:≥97% by HPLC Remarks:BIBU 1361 dihydrochloride is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM) with ~ 100-fold lower potency than ErbB2 (IC50 = 290 nM) and selectivity over a range
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| | BIBU 1361 DIHYDROCHLORIDE Basic information |
| Product Name: | BIBU 1361 DIHYDROCHLORIDE | | Synonyms: | N-(3-CHLORO-4-FLUOROPHENYL)-6-[4-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]-PYRIMIDO[5,4-D]PYRIMIDIN-4-AMINE DIHYDROCHLORIDE;BIBU 1361 DIHYDROCHLORIDE;N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-aminedihydrochloride;N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]pyrimido[5,4-d]pyrimidin-4-amine;BIBU 1361;BIBU1361
(BIBU 1361 );Pyrimido[5,4-d]pyrimidin-4-amine, N-(3-chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]- | | CAS: | 793726-84-8 | | MF: | C22H27ClFN7 | | MW: | 443.95 | | EINECS: | | | Product Categories: | | | Mol File: | 793726-84-8.mol |  |
| | BIBU 1361 DIHYDROCHLORIDE Chemical Properties |
| Boiling point | 580.0±60.0 °C(Predicted) | | density | 1.285±0.06 g/cm3(Predicted) | | storage temp. | Desiccate at +4°C | | solubility | DMSO (Slightly), Methanol (Very Slightly) | | form | Solid | | pka | 10.32±0.25(Predicted) | | color | Yellow |
| | BIBU 1361 DIHYDROCHLORIDE Usage And Synthesis |
| Uses | BIBU 1361 Dihydrochloride, is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). It also blocks downstream EGFR signaling events such as MAPKK/MAPK activation. | | Biological Activity | Potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC 50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC 50 > 10 μ M). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice. | | references | [1]. antczak c, mahida jp, bhinder b, et al. a high-content biosensor-based screen identifies cell-permeable activators and inhibitors of egfr function implications in drug discovery. journal of biomolecular screening, 2012, 17(7): 885-899.
[2]. ghildiyal r, dixit d, sen e. egfr inhibitor bibu induces apoptosis and defective autophagy in glioma cells. molecular carcinogenesis, 2013, 52(12): 970-982. |
| | BIBU 1361 DIHYDROCHLORIDE Preparation Products And Raw materials |
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