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| (S)-1-Boc-3-hydroxymethyl-piperazine Basic information |
Product Name: | (S)-1-Boc-3-hydroxymethyl-piperazine | Synonyms: | (S)-1-Boc-3-hydroxymethyl-piperazine;(S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;(S)-4-Boc-2-(Hydroxymethyl)piperazine;H57160;1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3S)-;(S)-4-N-Boc-2-hydroxyMeth...;(S)-1-Boc-3-(hyroxyMethyl)piperazine;tert-butyl (3S)-3-(hydroxyMethyl)piperazine-1-carboxylate | CAS: | 314741-40-7 | MF: | C10H20N2O3 | MW: | 216.28 | EINECS: | | Product Categories: | Piperaizine | Mol File: | 314741-40-7.mol | ![(S)-1-Boc-3-hydroxymethyl-piperazine Structure](CAS/GIF/314741-40-7.gif) |
| (S)-1-Boc-3-hydroxymethyl-piperazine Chemical Properties |
Boiling point | 322.9±22.0 °C(Predicted) | density | 1.085±0.06 g/cm3(Predicted) | storage temp. | 2-8°C(protect from light) | pka | 14.97±0.10(Predicted) | CAS DataBase Reference | 314741-40-7 |
| (S)-1-Boc-3-hydroxymethyl-piperazine Usage And Synthesis |
Definition | (S)-1-Boc-3-hydroxymethyl-piperazine is also known as (S)-4-N-Boc-2-(hydroxymethyl)piperazine or (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate. | Uses | (S)-4-N-Boc-2-(hydroxymethyl)piperazine is a useful research chemical. | Synthesis | To synthesize (S)-1-Boc-3-hydroxymethyl-piperazine, a stirred suspension of (S)-piperazine-l,3-dicarboxylic acid l-tert-buty ester (5.00 g, 21.7 mmol) in THF (40 mL) was prepared. Slowly, 1.0 M borane-THF complex solution (32.6 mL, 32.6 mmol) was added to the suspension. The reaction mixture was heated to 90 ℃ and stirred under reflux for 2 h. Before further proceeding, the mixture was removed from heat and an additional 1.5 equivalents of 1.0 M borane-THF complex solution (32.6 mL, 32.6 mmol) was added. The reaction was then reheated and stirred under reflux for 2 h. Subsequently, the reaction mixture was cooled to 0 ℃ and quenched by slowly adding methanol. The resulting mixture was concentrated under reduced pressure, yielding a white solid. This solid was dissolved in THF (30 mL) and cooled to 0 ℃. Slowly, a 2.0 M solution of lithium aluminum hydride (LiAlH4) in THF (27 mL, 54.0 mmol) was added. The reaction was heated to 90 ℃ and stirred under reflux for 2 h. Another portion of 2.0 M LiAlH4 was added, and the reaction mixture was stirred under reflux for 4 hours, followed by overnight stirring at RT. The reaction mixture was then cooled to 0 ℃ and quenched by slowly adding 1.0 M aqueous sodium hydroxide (NaOH) solution until the exothermic reaction subsided. The product (S)-1-Boc-3-hydroxymethyl-piperazine was obtained after purification.
![(S)-1-Boc-3-hydroxymethyl-piperazine (S)-1-Boc-3-hydroxymethyl-piperazine](/NewsImg/2023-10-16/6383305003263800888357048.jpg) |
| (S)-1-Boc-3-hydroxymethyl-piperazine Preparation Products And Raw materials |
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