澳洲茄边碱
中文名称 | 澳洲茄边碱 |
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中文同义词 | 澳洲茄边碱(标准品);边缘茄碱;澳洲茄边碱(奥洲边茄碱);澳州茄边碱;澳洲茄边碱, >98%;Α-奥洲边茄碱;Α-SOLAMARGINE;(-)-澳洲茄边碱 |
英文名称 | Solamargine |
英文同义词 | SOLAMERGINE;δ-Solanigrine;2)-O-[6-deoxy-a-L-Mannopyranosyl-(1®b-D-Glucopyranoside, (3b,22a,25R)-spirosol-5-en-3-yl O-6-deoxy-a-L-Mannopyranosyl-(1®(3β,22α,25R)-Spirosol-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1→2)-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside;[(22R,25R)-Spirosola-5-ene-3β-yl]2-O,4-O-bis(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside;(3beta,22alpha,25R)-spirosol-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside;NSC 407810 |
CAS号 | 20311-51-7 |
分子式 | C45H73NO15 |
分子量 | 868.06 |
EINECS号 | |
相关类别 | 植物提取物;对照品;植提标准品;中药对照品;标准品;Alkaloids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-中药标准品;标准品 -中药标准品;标准品,对照品 |
Mol文件 | 20311-51-7.mol |
结构式 |
澳洲茄边碱 性质
熔点 | 301 °C |
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密度 | 1.38 |
储存条件 | Refrigerator |
溶解度 | 可溶于DMSO(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | 12?+-.0.70(Predicted) |
颜色 | 浅米色低熔点 |
Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis.
Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC
50
s are 9.21 and 19.88 μg/ml, respectively.
Cell Viability Assay
Cell Line: | SMMC-7721cells |
Concentration: | 15 μg/ml |
Incubation Time: | 72 hours |
Result: | Displayed a significant increase of sub-G1. |
Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo.
Animal Model: | Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old) |
Dosage: | 10 mg/kg |
Administration: | Intragastric administration; once daily for 8 days |
Result: | Tumor growth was significantly inhibited . |
药理药效:牛皮癣、皮肤瘙痒及多种癌症治疗