| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Bupranolol
CAS:14556-46-8
Package:500Mg,5g
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| Company Name: |
Hangzhou Sage Chemical Co., Ltd.
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| Tel: |
+86057186818502 13588463833 |
| Email: |
info@sagechem.com |
| Products Intro: |
Product Name:2-Propanol, 1-(2-chloro-5-Methylphenoxy)-3-[(1,1-diMethylethyl)aMino]-
CAS:14556-46-8
Purity:98% Package:1g;5g;100g;Bulk
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| | Bupranolol Basic information |
| Product Name: | Bupranolol | | Synonyms: | (2S)-1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol;(S)-1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol;1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol;1-(tert-Butylamino)-3-[(6-chloro-m-tolyl)oxy]-2-propanol;1-[(2-Chloro-5-methylphenyl)oxy]-3-[(1,1-dimethylethyl)amino]propan-2-ol;Bupranolol;2-Propanol, 1-(2-chloro-5-methylphenoxy)-3-[(1,1-dimethylethyl)amino]-;2-Propanol, 1-(tert-butylamino)-3-[(6-chloro-m-tolyl)oxy]- (8CI) | | CAS: | 14556-46-8 | | MF: | C14H22ClNO2 | | MW: | 271.78 | | EINECS: | | | Product Categories: | | | Mol File: | 14556-46-8.mol |  |
| | Bupranolol Chemical Properties |
| Melting point | 71-74°C | | Boiling point | 396.3±42.0 °C(Predicted) | | density | 1.098±0.06 g/cm3(Predicted) | | storage temp. | Hygroscopic, Refrigerator, Under Inert Atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 13.82±0.20(Predicted) | | color | White to Off-White |
| | Bupranolol Usage And Synthesis |
| Originator | Betadrenol,Pharma-Schwarz,W. Germany,1969 | | Uses | Bupranolol is an antagonist at the cardiostimulatory low-affinity state of b(1)-adrenoceptors and is known to treat hypertension and tachycardia. | | Definition | ChEBI: Bupranolol is an aromatic ether. | | Manufacturing Process | A mixture of 16.3 g of (2-chloro-5-methylphenyl)glycidic ether (from
epichlorohydrin and 2-chloro-5-methylphenol) and 6.2 g of t-butylamine in 50
ml of ethanol is heated at reflux for 6 hours. The solvent is removed, the
residue is washed with water and then extracted with benzene. The dried
extract is evaporated to give 1-t-butylamino-3-(2-chloro-5-methylphenoxy)-2-
propanol. Treatment of the free base in benzene solution with dry hydrogen
chloride yields the hydrochloride salt. | | Therapeutic Function | Antiarrhythmic |
| | Bupranolol Preparation Products And Raw materials |
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