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| Rutamycin Basic information |
Product Name: | Rutamycin | Synonyms: | 26-Demethyloligomycin A;A-272;RR-32705;RRNo-32705;RutaMycin, 26-deMethyloligoMycin A, A 272, RR 32705, RutaMycin A;Rutamycin;oligomycin D;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethyl-,(1S,2'R,4E,5'S,6S,6'S,7S,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,29R)- | CAS: | 1404-59-7 | MF: | C44H72O11 | MW: | 777.042 | EINECS: | | Product Categories: | | Mol File: | 1404-59-7.mol | |
| Rutamycin Chemical Properties |
Melting point | 116-119° | alpha | D20 -62° (c = 1.36 in CHCl3) | Boiling point | 883.4±65.0 °C(Predicted) | density | 1.15±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | form | A lyophilisate | pka | 12.52±0.70(Predicted) |
RIDADR | 2811 | HazardClass | 6.1(b) | PackingGroup | III | Toxicity | LD50 oral in mouse: 800mg/kg |
| Rutamycin Usage And Synthesis |
Description | Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F1FO-ATPase and is used to uncouple oxidative phosphorylation from electron transport. Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM and is cytotoxic to SW620 colon cancer cells with an IC50 value of 36 μM. | Uses | Oligomycin D is an inhibitor of mitochondrial F1F0-ATPase. | Uses | Oligomycin D (rutamycin) is macrocyclic lactone belonging to the oligomycin class but identified from different species of Streptomyces in 1961. Like oligomycin A, oligomycin D inhibits mitochondrial F1F0-ATPase and is an important bioprobe to study the organisation of ATPase on the mitochondrial membrane. Oligomycin D exhibits a broad biological profile including antifungal, antitumor and nematocidal activities. |
| Rutamycin Preparation Products And Raw materials |
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