溴法罗明
| 中文名称 | 溴法罗明 |
|---|---|
| 中文同义词 | 化合物 T10617 |
| 英文名称 | Brofaromine |
| 英文同义词 | 4-(7-bromo-5-methoxybenzofuran-2-yl)piperidine;4-(7-Bromo-5-methoxy-1-benzofuran-2-yl)piperidine;Piperidine, 4-(7-bromo-5-methoxy-2-benzofuranyl)- |
| CAS号 | 63638-91-5 |
| 分子式 | C14H16BrNO2 |
| 分子量 | 310.19 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 63638-91-5.mol |
| 结构式 |  |
溴法罗明 性质
| 沸点 | 404.0±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.386±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：250 mg/mL（805.96 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.99±0.10(Predicted) |
| 颜色 | 米白色至浅黄色 |
Brofaromine (CGP 11305A) 是一种单胺氧化酶 (MAO) 抑制剂，抑制 MAO-A，IC50 为 0.2 μM。
IC50: 0.2 μM (MAO-A)
In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC 50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC 50 range of Brofaromine is 0.01 μM to 0.1 μM.