| Company Name: |
Jiangsu yize medical technology co. LTD
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| Tel: |
18550739526 |
| Email: |
23903480@qq.com |
| Products Intro: |
Product Name:4-(7-Bromo-5-methoxy-1-benzofuran-2-yl)piperidine
CAS:63638-91-5
Purity:95% Package:1g/
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Brofaromine
CAS:63638-91-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | Brofaromine Basic information |
| Product Name: | Brofaromine | | Synonyms: | 4-(7-bromo-5-methoxybenzofuran-2-yl)piperidine;4-(7-Bromo-5-methoxy-1-benzofuran-2-yl)piperidine;Piperidine, 4-(7-bromo-5-methoxy-2-benzofuranyl)- | | CAS: | 63638-91-5 | | MF: | C14H16BrNO2 | | MW: | 310.19 | | EINECS: | | | Product Categories: | | | Mol File: | 63638-91-5.mol |  |
| | Brofaromine Chemical Properties |
| Boiling point | 404.0±45.0 °C(Predicted) | | density | 1.386±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 250 mg/mL (805.96 mM) | | form | Solid | | pka | 9.99±0.10(Predicted) | | color | Off-white to light yellow |
| | Brofaromine Usage And Synthesis |
| Biological Activity | Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor, inhibits MAO-A with IC50 of 0.2 μM. | | in vitro | In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC 50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC 50 range of Brofaromine is 0.01 μM to 0.1 μM. | | target | |
| | Brofaromine Preparation Products And Raw materials |
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