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| | GLY-ARG-GLY-ASP-SER-PRO-LYS Basic information |
| Product Name: | GLY-ARG-GLY-ASP-SER-PRO-LYS | | Synonyms: | H-GLY-ARG-GLY-ASP-SER-PRO-LYS-OH;GRGDSPK;GRGDSPK, FIBRONECTIN ATTACHMENT PEPTIDE;GLY-ARG-GLY-ASP-SER-PRO-LYS;GLY-ARG-GLY-ASP-SER-PRO-LYS ACETATE;glycyl- arginyl-glycyl-aspartyl-seryl-prolyl-lysine;EMD 56574;L-Lysine, glycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl- | | CAS: | 111119-28-9 | | MF: | C28H49N11O11 | | MW: | 715.76 | | EINECS: | | | Product Categories: | peptide | | Mol File: | 111119-28-9.mol |  |
| | GLY-ARG-GLY-ASP-SER-PRO-LYS Chemical Properties |
| density | 1.59±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | pka | 3.60±0.21(Predicted) | | form | Solid | | color | White to off-white |
| | GLY-ARG-GLY-ASP-SER-PRO-LYS Usage And Synthesis |
| Uses | Gly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used-
- as a blocking peptide to inhibit integrin-fibronectin binding
- in adhesion assay performed on porcine trophectoderm to study the influence of TGFβ (transforming growth factor) on cell adhesion
- for incubation of MC3T3-E1 osteoblast cells to determine its effect on cell adhesion measured by AFM (atomic force microscopy)
- for the preparation of RGD.Flt23k.NR nanoparticles
- to determine the involvement of RGD-integrin bonding in cell adhesion process
| | General Description | Gly-Arg-Gly-Asp-Ser-Pro-Lys is a RGD peptide. Naturally occurring RGD peptides, present in the ECM (extracellalar matrix) proteins, are involved in facilitating integrin-mediated cell adhesion to matrix proteins. RGD peptide is present as repeats in cell-adhesion protein, such as fibronectin and vitronectin. This tripeptide is recognized by cells by specific integrins (e.g. β1 , β3 , and β5 subunits), present on the cell surface and associated with the actin filament via the FA (focal adhesion)-complex. | | Biochem/physiol Actions | Fibronectin analog that binds to integrins. |
| | GLY-ARG-GLY-ASP-SER-PRO-LYS Preparation Products And Raw materials |
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