款冬酮
| 中文名称 | 款冬酮 |
|---|---|
| 中文同义词 | 款冬素,款冬花素,款冬花酮;款冬素,款冬花素;款冬酮(款冬素,款冬花素,款冬花酮;款冬酮, 来源于款冬花;款冬酮(分析标准品);款冬素;款冬酮(款冬素;款冬酮 |
| 英文名称 | Tussilagone |
| 英文同义词 | Tussilagone;L 652469;Tussilagone, 98%, from Farfarae Flos;2-Pentenoic acid, 3-methyl-, (1S,3aR,5R,7S,7aS)-1-[(1R)-1-(acetyloxy)ethyl]octahydro-4-methylene-7-(1-methylethyl)-2-oxo-1H-inden-5-yl ester, (2E)-;(1R,3aR,5R,7S,7aS)-1-(1-acetyloxyethyl)-4-methylidene-2-oxo-7-propan-2-yl-3,3a,5,6,7,7a-hexahydro-1H-inden-5-yl](E)-3-methylpent-2-enoate;(1S,3aR,5R,7S,7aS)-1-((R)-1-Acetoxyethyl)-7-isopropyl-4-methylene-2-oxooctahydro-1H-inden-5-yl (E)-3-methylpent-2-enoate;Tussilagone-RM |
| CAS号 | 104012-37-5 |
| 分子式 | C23H34O5 |
| 分子量 | 390.51 |
| EINECS号 | |
| 相关类别 | 标准品;对照品;中药对照品;分析试剂标准品;对照品-中药对照品;倍半萜;标准品，对照品 |
| Mol文件 | 104012-37-5.mol |
| 结构式 |  |
款冬酮 性质
| 沸点 | 471.3±35.0 °C(Predicted) |
|---|---|
| 密度 | 1.07±0.1 g/cm3 (20 ºC 760 Torr) |
| 储存条件 | 2-8°C |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| InChIKey | CFUPNMDNSQIWBB-UUVDBSHOSA-N |
| SMILES | C(O[C@@H]1C[C@@H](C(C)C)[C@@]2([H])[C@]([H])(C1=C)CC(=O)[C@@H]2[C@H](OC(C)=O)C)(=O)/C=C(\C)/CC |
Tussilagone suppressed the expression of the inflammatory mediators, nitric oxide and prostaglandin E2, and the inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and high-mobility group box 1 (HMGB1), in lipopolysaccharide-stimulated RAW 264.7 cells and peritoneal macrophages. Tussilagone also reduced the activation of the mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) involved in the activation of various inflammatory mediators in activated macrophages.
Tussilagone administration (1 mg/kg and 10 mg/kg) produced decreased mortality and lung injury in CLP-activated septic mice. Augmented expression of cyclooxygenase (COX)-2 and TNF-α in pulmonary alveolar macrophages of septic mice were attenuated by tussilagone administration.
药理药效:有升压、呼吸兴奋作用
安全信息
| 安全说明 | 24/25 |
|---|---|
| 海关编码 | 29389090 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-N1388 | 款冬酮 Tussilagone | 104012-37-5 | 1 mg | 480元 |
| 2025/05/22 | HY-N1388 | 款冬酮 Tussilagone | 104012-37-5 | 10 mM * 1 mLin DMSO | 1027元 |