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Alfa Chemistry
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Product Name:3-hydrazinoquinoxaline-2-thiol
CAS:13080-21-2
Purity:95% Package:1g;10g;100g;1KG;5KG
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| | 3-HYDRAZINO-QUINOXALINE-2-THIOL Basic information |
| Product Name: | 3-HYDRAZINO-QUINOXALINE-2-THIOL | | Synonyms: | CHEMBRDG-BB 5215319;AKOS BBS-00008251;3-HYDRAZINO-QUINOXALINE-2-THIOL;3-hydrazinoquinoxaline-2-thiol(SALTDATA: FREE);3-Hydrazinylquinoxaline-2(1H)-thione;3-Hydrazinylquinoxaline-2-thiol;2(1H)-Quinoxalinethione, 3-hydrazinyl-;membranes,Helicobacter,ulcer,Antimicrobial,gastric,HPi1,inhibit,Inhibitor,Bacterial,permeate,HPi 1,HPi-1,orally,pylori,peptic | | CAS: | 13080-21-2 | | MF: | C8H8N4S | | MW: | 192.24 | | EINECS: | | | Product Categories: | | | Mol File: | 13080-21-2.mol |  |
| | 3-HYDRAZINO-QUINOXALINE-2-THIOL Chemical Properties |
| Melting point | 254 °C (decomp)(Solv: ethanol (64-17-5)) | | Boiling point | 376.1±25.0 °C(Predicted) | | density | 1.55±0.1 g/cm3(Predicted) | | pka | 7.91±0.20(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | 3-HYDRAZINO-QUINOXALINE-2-THIOL Usage And Synthesis |
| Biological Activity | HPi1 is a potent, selective and orally active antibacterial agent against Helicobacter pylori with IC50 of 0.24 μM and MIC of 0.08-0.16 μg/mL. It is inactive against other bacteria, including the enteric bacteria Lactobacillus casei, Lactobacillus reuteri and Bifidobacterium longum. | | in vitro | The MIC against H. pylori isolates ranged from 0.002-0.032 μg/mL (0.01-0.17 μM) in the agar dilution assay. HPi1 is effective against the clarithromycin-resistant strains ARHp172 (MIC of 0.004–0.016 μg/mL) and ARHp246 (MIC of 0.008–0.032 μg/mL).
HPi1 has some activity against the Bacteroides species , but at concentrations at least 18- fold higher than the H. pylori MIC. More potent activity is detected for Campylobacter jejuni with an MIC of 0.3 μg/mL.
HPi1 has good physicochemical and pharmacological properties, including determining the aqueous solubility (19 μg/mL), human plasma protein binding (93% bound), stability with human liver microsomes (T 1/2 of 1.3 hours) and the ability to passively permeate membranes. | | target | IC50: 0.24 μM ( Helicobacter pylori )
MIC: 0.08-0.16 μg/mL ( Helicobacter pylori ) |
| | 3-HYDRAZINO-QUINOXALINE-2-THIOL Preparation Products And Raw materials |
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