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| | Mozavaptan Hydrochloride
Basic information |
| Product Name: | Mozavaptan Hydrochloride
| | Synonyms: | N-[4-[[5-(Dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methylbenzamide hydrochloride;5-(Dimethylamino)-1-[4-(2-methylbenzamido)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride;N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide hydrochloride;OPC 31260 hydrochloride;Mozavaptan HCl;MOROBKPIULFQDC-UHFFFAOYSA-N;OPC 31260 hydrochloride >=98% (HPLC);Benzamide,N-[4-[[5-(dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methyl-,hydrochloride (1:1) | | CAS: | 138470-70-9 | | MF: | C27H29N3O2.ClH | | MW: | 464.006 | | EINECS: | | | Product Categories: | | | Mol File: | 138470-70-9.mol |  |
| | Mozavaptan Hydrochloride
Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: ≥15mg/mL | | form | powder | | color | white to tan |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | Mozavaptan Hydrochloride
Usage And Synthesis |
| Uses | Mozavaptan is a benzazepine derivative that antagonizes the binding of arginine vasopressin (AVP) to vasopressin receptors located in the liver (V1; IC50 = 1.2 μM) and kidney (V2; IC50 = 14 nM). At 10-100 μg/kg, mozavaptan can inhibit the antidiuretic action of AVP, promoting aquaresis when administered intravenously to rats. The therapeutic potential of mozavaptan in ectopic antidiuretic hormone syndrome, heart failure, and other complications related to hyponatremia has been studied. | | Definition | ChEBI: Mozavaptane hydrochloride is a member of benzamides. | | Biochem/physiol Actions | OPC 31260 is a vasopressin V2 selective antagonist. Arginine vasopressin (AVP) plays an important part in circulatory and water homeostasis. The V2 receptor subtype is important in water retention, cardiac remodeling in congestive heart failure (CHF), and renal hemodynamic alterations, and is considered a target for polysystic kidney disease. OPC-31260 has been shown to inhibit the development of polycystic kidney disease in several animal models. |
| | Mozavaptan Hydrochloride
Preparation Products And Raw materials |
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