- Teneligliptin
-
- $167.00 / 1g
-
2024-06-12
- CAS:760937-92-6
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 1000
- Teneligliptin
-
- $0.00/ kg
-
2024-05-09
- CAS:760937-92-6
- Min. Order: 1kg
- Purity: 99%, Single impurity<0.1
- Supply Ability: 1 ton
- Teneligliptin
-
- $0.00 / 1KG
-
2022-09-16
- CAS:760937-92-6
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1ton
|
| Teneligliptin Basic information |
Product Name: | Teneligliptin | Synonyms: | teneligliptin;3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine;Methanone,[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-;Teneligptin WS;[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone;API (Teneligliptin free base);Teliglietin;Teneligliptin (MP-513) | CAS: | 760937-92-6 | MF: | C22H30N6OS | MW: | 426.58 | EINECS: | | Product Categories: | | Mol File: | 760937-92-6.mol | |
| Teneligliptin Chemical Properties |
Melting point | >100°C (dec.) | Boiling point | 663.4±55.0 °C(Predicted) | density | 1.38 | storage temp. | Refrigerator | solubility | DMSO (Slightly), Methanol (Slightly) | form | Solid | pka | 8.70±0.10(Predicted) | color | Off-White |
| Teneligliptin Usage And Synthesis |
Description | Teneligliptin was approved in September 2012 in Japan for the treatment of patients with Type 2 diabetes mellitus (T2DM). Teneligliptin is a member of the dipeptidyl peptidase 4 (DPP-4) inhibitor class of antidiabetes agents. DPP-4 is an enzyme that degrades GLP-1, a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Teneligliptin is one of a growing numbers of DPP-4 inhibitors to be approved worldwide. The discovery of teneligliptin was guided by structure-based design, with a key element being binding of the phenyl group in the S2 pocket, which not only increases potency for DPP-4, but also improves selectivity versus DPP-8 and DPP- 9. Teneligliptin is a potent inhibitor of DPP-4 in the enzyme inhibition assay (IC50=0.37 nM). | Originator | Mitsubishi Tanabe Pharma (Japan) | Uses | Teneligliptin, is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body. | Definition | ChEBI: Teneligliptin is an amino acid amide. | Brand name | Tenelia |
| Teneligliptin Preparation Products And Raw materials |
|