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| 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Basic information |
Product Name: | 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL | Synonyms: | 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL;1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanonehydrochloride;1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one hydrochloride;Antitrypanosomal agent 1;1-Propanone1-(34-dichlorophenyl)-3-(dimethylamino)-hydrochloride;1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one;Antitrypanosomal agent-1,Antitrypanosomal agent 1,T.brucei,trypanothione,inhibit,glutathione,Antitrypanosomal agent1,Inhibitor,reductase,Parasite,anti-trypanosomal | CAS: | 75144-12-6 | MF: | C11H14Cl3NO | MW: | 282.59 | EINECS: | | Product Categories: | | Mol File: | 75144-12-6.mol | ![1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Structure](CAS/GIF/75144-12-6.gif) |
| 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Chemical Properties |
Melting point | 186 - 188°C | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | solubility | DMSO (Slightly), Methanol (Slightly) | form | Solid | color | Off-White | Water Solubility | Water: 10 mg/mL (35.39 mM) |
| 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Usage And Synthesis |
Biological Activity | Antitrypanosomal agent 1 is a potent and selective inhibitor of trypanothione reductase with IC50 of 3.3 μM. It inhibits glutathione reductase with IC50 of 64.8 μM; inhibits Trypanosoma brucei with EC50 of 1 μM. It has antitrypanosomal activity. | in vitro | Antitrypanosomal agent 1 (compound 8a) has an selectivity for TR (GR IC50/TR IC50) of 20. | target | IC50: 3.3 μM (trypanothione reductase) and 64.8 μM (glutathione reductase) EC50: 1 μM ( T. brucei ) |
| 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL Preparation Products And Raw materials |
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