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| | 2'-OMe-ibu-G Phosphoramidite Basic information |
| Product Name: | 2'-OMe-ibu-G Phosphoramidite | | Synonyms: | 2’-O-Methy-rG(N-ibu)Phosphoramidite;N-blocked-5'-O-DMT-2'-O-Me CED guanosine phosphoramidite;5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite;5'-O-DMT-2'-O-Me-rG(N-iBu)-3'-CEDPA;2'-OMe-ibu-G Phosphoramidite;5'-O-DMT-2'-O-Me-G(ibu) phosporamidite;DMT-2′O-Methyl-rG(ib) Phosphoramidite;2'-O-Methyl-N2-Isobutyryl-5'-O-DMT-Guanosine-3'-CE-Phosphoramidite | | CAS: | 150780-67-9 | | MF: | C45H56N7O9P | | MW: | 869.94 | | EINECS: | 2017-001-1 | | Product Categories: | Amidite | | Mol File: | 150780-67-9.mol |  |
| | 2'-OMe-ibu-G Phosphoramidite Chemical Properties |
| Melting point | 138 - 140°C | | storage temp. | Inert atmosphere,2-8°C | | solubility | Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly, Sonicated) | | form | powder | | pka | 9.16±0.20(Predicted) | | color | white to off-white | | InChIKey | IRRDHRZUOZNWDJ-MLLDKZSOSA-N | | SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,44,47,r| |
| | 2'-OMe-ibu-G Phosphoramidite Usage And Synthesis |
| Chemical Properties | The IUPAC Name is N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
| | Uses | 2''-OMe-ibu-G Phosphoramidite (CAS# 150780-67-9) is used in the synthesis of native-like crosslinked duplex RNA via interstrand crosslinking reaction between vinylpurine on one strand and target cytosine or uracil on the opposite strand. | | Definition | 2'-OMe-ibu-G Phosphoramidite is a chemically unstable and heat-sensitive nucleoside phosphoramidite that serves as a foundational element in oligonucleotide synthesis. 2'-OMe-RNA CE (β-cyanoethyl) Phosphoramidites are designed to produce synthetic oligonucleotides containing nuclease resistant 2'-O-methyl ribonucleotide linkages. Deprotection, isolation and handling of 2'-O-methyl oligonucleotides are identical to the procedures for oligodeoxynucleotides. |
| | 2'-OMe-ibu-G Phosphoramidite Preparation Products And Raw materials |
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