QX-314
中文名称 | QX-314 |
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中文同义词 | 化合物QX-314 CHLORIDE;QX-314氯化物(N-乙基乙卡因氯化物) |
英文名称 | QX 314 chloride |
英文同义词 | QX 314 CHLORIDE;N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE;QX314.Cl;2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride;[2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride;[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride;[2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride;Lidocaine N-ethyl chloride |
CAS号 | 5369-03-9 |
分子式 | C16H27ClN2O |
分子量 | 298.85 |
EINECS号 | |
相关类别 | Ion Channels |
Mol文件 | 5369-03-9.mol |
结构式 |
QX-314 性质
熔点 | 209-211 °C |
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储存条件 | Room temp |
溶解度 | 不溶于乙醇; DMSO 中≥14.95 mg/mL,温和加热;水中≥22.3 mg/mL |
形态 | 固体 |
颜色 | 白色 |
水溶解性 | Soluble in water (100mM) |
sodium channel
QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro.
QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner.
QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca
2+
currents are on average < 45% of control amplitude.
安全信息
安全说明 | 22-24/25 |
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WGK Germany | 3 |
提供商 | 语言 |
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英文
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