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Product Name:N-Methylleukotriene C4 CAS:131391-65-6 Purity:97% Package:1g;10g;100g;1KG;5KG
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Product Name:N-methyl Leukotriene C4 CAS:131391-65-6 Purity:>98% Package:1mg;10mg;50mg;100mg;
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Product Name:N-methyl Leukotriene C4 CAS:131391-65-6 Purity:≥97% Remarks:N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of Leukotriene C4 (LTC4) that is not readily metabolized to LTD4 and LTE4. It acts as a potent and selective CysLT2 receptor agonist.
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Product Name:N-methyl Leukotriene C4 CAS:131391-65-6 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Product Name:N-methylLeukotrieneC4 CAS:131391-65-6 Purity:NULL Package:25g;50g Remarks:NULL
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| N-Methylleukotriene C4 Basic information |
Product Name: | N-Methylleukotriene C4 | Synonyms: | N-[S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-N-(L-γ-glutamyl)-L-cysteinyl]-N-methylglycine;N-Methylleukotriene C4;NMLTC4;N-METHYL LTC4;FPLBRCJNODNRQZ-UYCXAPQFSA-N;Glycine, N-methyl-L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteinyl-;N methyl Leukotriene C4,N-methyl Leukotriene C-4,Nmethyl Leukotriene C4 | CAS: | 131391-65-6 | MF: | C31H49N3O9S | MW: | 639.81 | EINECS: | | Product Categories: | | Mol File: | 131391-65-6.mol | |
| N-Methylleukotriene C4 Chemical Properties |
Boiling point | 965.7±65.0 °C(Predicted) | density | 1.202±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; Ethanol:H20 (95:5): 2 mg/ml; PBS (pH 7.2): 100 μg/ml | pka | 2.23±0.10(Predicted) |
| N-Methylleukotriene C4 Usage And Synthesis |
Uses | N-methyl Leukotriene C4 is synthetic analog of LTC4 with decreased binding affinity. | Uses | Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukotriene C4 (N-methyl LTC4) is a synthetic analog of LTC4 that is not readily metabolized to LTD4 and LTE4.It acts as a potent and selective CysLT2 receptor agonist exhibiting EC50 values of 122 and > 2,000 nM at the human CysLT2 and CysLT1 receptors, respectively. It has essentially the same potency as LTC4 at both the human and murine receptors CysLT2 receptors. N-methyl LTC4 is potent and active in vivo, causing vascular leak in mice overexpressing the human CysLT2 receptor but not in CysLT2 receptor knockout mice. |
| N-Methylleukotriene C4 Preparation Products And Raw materials |
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