Company Name: |
Sigma-Aldrich
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Tel: |
021-61415566 800-8193336 |
Email: |
orderCN@merckgroup.com |
Products Intro: |
Product Name:MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem
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Company Name: |
Yantai Lianhua Technology Co., Ltd
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Tel: |
15552437730 |
Email: |
1701654643@qq.com |
Products Intro: |
Product Name:trans-4-iodo-4'-boranyl-chalcone CAS:562823-84-1 Purity:95%+ Package:50G;100G
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| 3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Basic information |
| 3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Chemical Properties |
storage temp. | +2C to +8C | solubility | DMSO: >30 mg/mL, soluble | form | solid |
| 3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Usage And Synthesis |
Definition | ChEBI: [4-[3-(4-iodophenyl)prop-2-enoyl]phenyl]boronic acid is a member of chalcones. | General Description | A cell-permeable boranyl-chalcone compound that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex formation. Exhibits selective toxicity to MDM2-overexpressing human breast cancer cell lines (IC50 = 10 μM for MDA-MB-435, 8.8 μM for MDA-MB-231, and 7 μM for Wt-MCF7) compared to normal breast cell lines (IC50 = 75 μM for MCF-10A and 63 μM for MCF-12A). | Biochem/physiol Actions | Cell permeable: yes |
| 3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Preparation Products And Raw materials |
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