| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:5-Chloro-1-[(4-chlorophenyl)Methyl]-3-(phenylthio)-1H-indole-2-carboxylic Acid
CAS:118414-59-8
Package:100Mg,10Mg,50Mg
|
| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:nTZDpa;5-Chloro-1-[(4-chlorophenyl)Methyl]-3-(phenylthio)-1H-indole-2-carboxylicacid
CAS:118414-59-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
| Company Name: |
Shanghai TaoSu Biochemical Technology Co., Ltd.
|
| Tel: |
021-33632979 |
| Email: |
info@tsbiochem.com |
| Products Intro: |
Product Name:5-Chloro-1-[(4-chlorophenyl)Methyl]-3-(phenylthio)-1H-indole-2-carboxylic Acid
CAS:118414-59-8
Purity:90% Package:10Mg;50Mg;100Mg;
|
| Company Name: |
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
|
| Tel: |
025-66113011 18112977050 |
| Email: |
cb6@aikonchem.com |
| Products Intro: |
Product Name:5-Chloro-1-(4-chlorobenzyl)-3-(phenylthio)-1H-indole-2-carboxylic acid
CAS:118414-59-8
Purity:95+% Package:1g;5g;10g
|
|
| | 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID Basic information |
| | 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID Chemical Properties |
| storage temp. | Store at +4°C | | solubility | DMSO: soluble15mg/mL, clear | | form | powder | | color | white to beige |
| RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| | 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID Usage And Synthesis |
| Uses | nTZDpa is a PPARγ agonist, with pharmaceutical applications such as anti-diabetic drugs. | | Biological Activity | Potent, selective non-thiazolidinedione PPAR γ partial agonist (EC 50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC 50 ~ 285 nM). Displays no activity at PPAR α or PPAR δ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPAR γ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo . | | storage | Store at +4°C |
| | 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID Preparation Products And Raw materials |
|